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Advanced Optical Bio-Imaging Platform

The Advanced Optical Bio-Imaging Platform, a part of NTU Optical Bio-Imaging Centre (NOBIC), provides an array of microscopes as well as related optical imaging expertise that caters to the imaging needs of LKCMedicine researchers and the NTU Community. Our imaging expertise ranges from simple preparation, fluorescent labelling, advanced microscropy and micro-spectroscopy techniques to microscopy image processing and analysis. 

The microscopes are currently located at LKCMedicine's Clinical Sciences Building @ Novena Campus, Experimental Medicine Building @ NTU Main Campus and Academia on SGH Campus. 

Their capabilities include: 

  • Imaging live/fixed cells and tissue sections with diffraction-limited resolution using wide-field and confocal microscopes
  • Resolving a few tens of nanometres in live/fixed cells with the N-STORM microscope
  • Performing calcium imaging in islet and islet cells in perifusion  
  • Volume-imaging of zebrafish embryo for developmental biological studies using a lightsheet microscope 
  • High-throughput screening/scanning using a HCS microscope/slide scanner 
  • Neuroimaging in animal models using optogenetics and in vivo deep-tissue imaging for metabolic studies using two-photon microscopes


Equipment 

NIKON ECLIPSE TI-E_EMB (Custom).png

​​ ​HIGH-CONTENT SCREENING MICROSCOPE.png (Custom).png
INVERTED CONFOCAL AIRYSCAN (Custom).png​ 
Fluorescence Microscopes ​​​​High Content
Scree​ning Microscopes
Inverted Confocal Microscopes

ZEISS LIGHTSHEET Z.1 (Custom).png 
LEICA DMI6000 (Custom).png 
MULTI-PHOTON MICROSCOPE FOR INVIVO IMAGING (Custom).png 
​​​Multi-Photon
Microscopes
​​24_ZEISS LSM800 (Custom).png

Calcium Imaging System (Custom).png
HIGH MODALITY TOTAL INTERNAL.png (Custom).png

SLIDE SCANNER_ZEISS (Custom).png

For the development of customised imaging setups, please approach the NOBIC team at nobic@e.ntu.edu.sg​. ​

For further enquiries, please contact Dr Balakrishnan Kannan at kbala@ntu.edu.sg. 
 

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