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Ion Channel Screening Platform

Ion channels are involved in diverse physiological processes and their malfunction causes numerous human diseases. Drugs that modulate ion channels account for the second largest group in the pharmacopeia. Methods to study ion channels include ligand-binding, flux-based and fluoroscence-based assays, but the best technology to study ion channel function and screen for compound interaction is the patch clamp technique. This technique is FDA-mandated in hERG (human ether-a-go-go-related gene) safety testing.

Equipment

Automated Sophion QPatch HTX (Custom).png
 
Manual inverted fluorescence (Custom).png
 
Manual upright fluorescence (Custom).png

Automated Sophion
QPatch HTX 
turnkey
screening station


Manual inverted fluorescence

Olympus IX73 patch 
clamp system

Manual upright fluorescence SliceScope Pro 6000 patch clamp system with IR-DIC​

  
70+ Ion Channel and Transporter Cell Lines ​
​- Voltage-gated potassium channels
- ​Calcium-activated potassium channels
- Inward-rectifier potassium channels
- Two-pore domain potassium channels
- Sodium channels
- Calcium channels
- TRP channels
- Acid-sensitive ion channels
​- Chloride channels

- Hyperpolarisation-activated cyclic nucleotide-gated ion channels
- GABA
- NMDA
- Ach
- 5-HT​​​

 

We provide high-quality patch clamp analysis for non-clinical cardiac safety assessment

according to the recommendations of the Comprehensive in vitro Proarrhythmia (CiPA)

initiative, a new strategy proposed by the FDA and other expert working groups such as

the Health and Environmental Sciences Institute (HESI) and Cardiac Safety Research

Consortium (CSRC).

 

We also perform pharmacology screening of ion channel modulators.

Facility Pricing Reference

Detailed pricing is available from ICESing Bioscience Pte Ltd, a local CRO that

partners the medical school through the LKCMedicine-ICESing Bioscience corporate

laboratory at NTU.​

For more details, please contact Dr Ong Seow Theng at st.ong@ntu.edu.sg​.


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