Basic research in chromosome biology has direct relevance to medical science as the disruption of genome integrity has multiple consequences, giving rise to a variety of human diseases, including those of the central nervous system, skin and musculoskeletal system as well as premature ageing and cancer.
Prof Daniela Rhodes, FRS, focuses on providing an understanding of the function of telomeres and telomerase at the molecular level. Her research is underpinned by Nanyang Institute of Structural Biology, a partnership between School of Biological Sciences and LKCMedicine that brings together expertise in methods such as nuclear magnetic resonance, X-ray crystallography and cryo-Electron Microscopy;
Nanyang Assoc Prof Karen Crasta studies events linking abnormal mitosis in cells to processes leading to diseases, with the long-term aim of identifying novel targets and developing combinatorial therapies; and
Nanyang Asst Prof Amartya Sanyal’s research focuses on the understanding of the 3D genome organisation and its impact on transcriptional regulatory code during mammalian development, differentiation and disease.