Developmental and Regenerative Biology have had an enormous impact on the life sciences over the past quarter century, through the elucidation of the gene regulatory networks controlling cell fate specification and differentiation as well as the discovery of embryonic stem cells. Developmental and Regenerative Biology thus underpin much of modern medical science and its teaching is central to any medical school graduate training programme.
Research in developmental and regenerative biology cuts across the four key vertical themes of LKCMedicine.
A major focus is on the Hedgehog signalling pathway, which plays pivotal roles in the development of the central nervous system as well as in skin tumorigenesis and has more recently been implicated in metabolic disease.
Analysis of the role of autophagy in zebrafish development will leverage on existing strengths in autophagy analysis in SBS and provide new opportunities for the use of animal models of autophagy function in infection and neurodegeneration.
Prof Philip W Ingham, FRS
, formerly of the MRC Centre for Developmental & Biomedical Genetics, University of Sheffield and Research Director at A*STAR IMCB. A world authority in developmental genetics and Hedgehog signalling, he will lead the Developmental Biology theme while Asst Prof Tom Carney's experience in zebrafish biology will complement and provide opportunities for the establishment of a zebrafish disease models and drug screening program.