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Overview

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In recent years, metabolomics have become increasingly important due to its potential to expand the understanding of how environmental factors and diseases influences human health. This can, in turn, lead to early disease diagnosis and prevention, or therapeutic strategies, resulting in improved healthcare and a higher standard of living. As such, the main research and service areas of the SPC are in the clinical, biological and environmental sciences. These research studies are centred on the profiling of critical biomolecules such as metabolites and lipids using the state-of-the-art Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS), and Nuclear Magnetic Resonance (NMR) Spectroscopy technologies available at SPC.

Singapore Phenome Centre offers a wide range of services including (but not limited to):
  • Profiling of metabolites in biological and clinical samples (urine, serum, plasma, fecal, etc) and samples from environmental sources via UPLC-MS and NMR.​
  • Quantification of targeted analyte compounds or metabolites from samples in biological, clinical and environmental studies, including (but not limited to): 
- ​Quantification of over 100 lipoprotein sub-fractions from plasma 
- Quantification of about 150 metabolites in urine 
- Stable isotop flux analysis 
- Quantification of 10 classes of phospholids (about 2750 phospholids)
- Quantification of amino acids 
- Quantification of TCA cycle intermediates 
- Quantification of a range of neurotransmitters
- Quantification of tryptophan metabolism 
- Quantification of bile acid metabolism 
- Quantification of choline metabolism 
- Quantification of arachidonic acid metabolism 
- Quantification of purine metabolism 
- Customer-tailored targeted metabolite analysis 

  • Mass Spectrometary Imaging
These services are offered on a fee-for-service basis. To set up projects with SPC, please complete the Project Details Form​​​, followed by contacting Centre Director Prof Wang Yulan (yulan.wang@ntu.edu.sg) or Centre Manager Dr Sunil Adav (s​sadav@ntu.edu.sg​) ​for a more detailed discussion.​ 
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