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Projects & Publications

Projects
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TARIPH’s initial research programme focuses on three inter-related thematic areas. The flagship project addresses our population, while the secondary projects focus on patients and healthy people. TARIPH projects will generate evidence on the presentation, course and consequence of respiratory illness in our patients and the population at large, work that will benefit Singaporeans with respiratory diseases and the maintenance of lung health.

Flagship project​​​​

  • Phenotypes of respiratory disease: A translational approach and analysis of service impact

    This project focuses on delineating clinical, mechanistic, behavioural and cultural differences across a range of chronic inflammatory respiratory disease states in Singapore including asthma, COPD, bronchiectasis, allergic rhinitis and allergy to better understand important clinically relevant and academic questions in primary, secondary and tertiary care settings.
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Secondary projects​​​​​​​

  • United airways care in the community

    The united airways concept recognises that upper and lower airway diseases often coexist, but this relationship and the resultant multi-morbidity is not readily recognised. Hence, this project aims to establish the prevalence of asthma and rhinitis amongst patients cared for in the community (general practices and polyclinics), the interventions that will be needed to improve management, and the feasibility of allergy testing in the primary care setting.
  • Healthy lungs for our workforce: Occupational associated respiratory consequences

    This study aims to assess lung health in healthy individuals across a range of occupational and community settings that expose sub-populations to potential airway insults. The effect of lifestyle factors will also be assessed with the intention of understanding how best to preserve lung health as our workforce ages.
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Please email us at TARIPH@ntu.edu.sg​ if you would like to know more about any of these projects or contribute as a member and collaborator to our work.
Publications

2020

Tiew, P. Y., Mac Aogain, M., Ali, N. A. t. B. M., Thng, K. X., Goh, K., Lau, K. J., & Chotirmall, S. H. (2020). The Mycobiome in Health and Disease: Emerging Concepts, Methodologies and Challenges. Mycopathologia, 1-25. doi: 10.1007/s11046-019-00413-z

Tiew, P. Y., San Ko, F. W., Narayana, J. K., Poh, M. E., Xu, H., Neo, H. Y., Loh, L. C., Ong, C. K., Aogáin, M. M., Ying Tan, J. H., Kamaruddin, N. H., Hui Sim, G. J., Lapperre, T. S., Koh, M. S., Cheong Hui, D. S., Abisheganaden, J. A., Tee, A., Tsaneva-Atanasova, K., & Chotirmall, S. H. (2020). 'High Risk' Clinical and Inflammatory Clusters in COPD of Chinese Descent. Chest, S0012-3692(20)30326-3. Advance online publication. ​doi: https://doi.org/10.1016/j.chest.2020.01.043 

Tiew, P. Y., Ko, F. W. S., Pang, S. L., Matta, S. A., Sio, Y. Y., Poh, M. E., Lau, K. J. X., Mac Aogáin M., Jaggi T.K., Ivan F.X., Gaultier N.E., Chotirmall, S. H. (2020). Environmental fungal sensitisation associates with poorer clinical outcomes in COPD. European Respiratory Journal, 2000418. doi:10.1183/13993003.00418-2020


2019

Ali, N., Mac Aogáin, M., Morales, R. F., Tiew, P. Y., & Chotirmall, S. H. (2019). Optimisation and benchmarking oftargeted amplicon sequencing for mycobiome analysis of respiratory specimens. International journal of molecular sciences, 20(20), 4991. doi: https://doi.org/10.3390/ijms20204991

Woo, L., Smith, H. E., & Sullivan, S. D. (2019). The Economic Burden of Chronic Obstructive Pulmonary Disease in the Asia-Pacific Region: A Systematic Review. Value in health regional issues, 18, 121-131. doi: https://doi.org/10.1016/j.vhri.2019.02.002

Molton, J. S., Thomas, B. A., Pang, Y., Khor, L. K., Hallinan, J., Naftalin, C. M., Totman, J. J., Townsend, D. W., Lim, T. K., Chee, C., Wang, Y. T., & Paton, N. I. (2019). Sub-clinical abnormalities detected by PET/MRI in household tuberculosis contacts. BMC infectious diseases, 19(1), 83. doi: https://doi.org/10.1186/s12879-019-3705-0

Budden, K. F., Shukla, S. D., Rehman, S. F., Bowerman, K. L., Keely, S., Hugenholtz, P., Armstrong-James, D.P., Adcock, I.M., Chotirmall, S.H., Chung, K.F., Hansbro, P. M. (2019). Functional effects of the microbiota in chronic respiratory disease. Lancet Respir Med, 7(10), 907-920. doi:10.1016/s2213-2600(18)30510-1

2018

Poh, T. Y., Ali, N. A. t. B. M., Mac Aogáin, M., Kathawala, M. H., Setyawati, M. I., Ng, K. W., & Chotirmall, S. H. (2018). Inhaled nanomaterials and the respiratory microbiome: clinical, immunological and toxicological perspectives. Particle and Fibre Toxicology, 15(1), 46. doi:10.1186/s12989-018-0282-0

Eguiluz‐Gracia, I., Tay, T. R., Hew, M., Escribese, M. M., Barber, D., O'hehir, R. E., & Torres, M. J. (2018). Recent developments and highlights in biomarkers in allergic diseases and asthma. Allergy. European Journal of Allergy and Clinical Immunology, 73(12), 2290-2305. doi: https://doi.org/10.1111/all.13628  

Mac Aogáin, M., Tiew, P. Y., Lim, A. Y. H., Low, T. B., Tan, G. L., Hassan, T., . . . Gwee, X. W. (2018). Distinct'Immuno-Allertypes' of Disease and High Frequencies of Sensitisation in Non-Cystic-Fibrosis Bronchiectasis. American Journal of Respiratory and Critical Care Medicine(ja). doi: https://doi.org/10.1164/rccm.201807-1355OC

McDonald, V. M., Hiles, S. A., Godbout, K., Harvey, E. S., Marks, G. B., Hew, M., Peters, M., Bardin, P. G., Reynolds, P. N., Upham, J. W., Baraket, M., Bhikoo, Z., Bowden, J., Brockway, B., Chung, L. P., Cochrane, B., Foxley, G., Garrett, J., Jayaram, L., Katelaris, C. J. C., Katsoulotos, G., Koh, M. S., et al. (2018). Treatable traits can be identified in a severe asthma registry and predict future exacerbations. Respirology.​ doi: https://doi.org/10.1111/resp.13389

Yii, A. C., Soh, A. Z., Chee, C. B., Wang, Y. T., Yuan, J.-M., & Koh, W.-P. (2018). Asthma, Sinonasal Disease, and the Risk of Active Tuberculosis. The Journal of Allergy and Clinical Immunology: In Practice. doi: https://doi.org/10.1016/j.jaip.2018.07.036

Ong, A. S. Q., Tan, A. H., Anantham, D., Sharma, K., Tan, S., Lapperre, T. S., . . . Koh, M. S. (2018). Impact of simulation training on performance and outcomes of endobronchial ultrasound-guided transbronchial needle aspiration performed by trainees in a tertiary academic hospital. Journal of thoracic disease, 10(9), 5621. doi: https://dx.doi.org/10.21037/jtd.2018.08.76

Mac Aogáin, M., Chandrasekaran, R., Lim, A. Y. H., Low, T. B., Tan, G. L., Hassan, T., . Chotirmall, S. H. (2018). Immunological corollary of the pulmonary mycobiome in bronchiectasis: the CAMEB study. European Respiratory Journal, 52(1), 1800766. doi:10.1183/13993003.00766-2018

Tay, T. R., Lee, J. W., & Hew, M. (2018). Diagnosis of severe asthma. Med J Aust, 209(2 Suppl), S3-S10. doi: https://doi.org/10.5694/mja18.00125

Tran, T.-T., Vidaillac, C., Yu, H., Yong, V. F., Roizman, D., Chandrasekaran, R., . . . Abisheganaden, J. A. (2018). A new therapeutic avenue for bronchiectasis: dry powder inhaler of ciprofloxacin nanoplex exhibits superior ex vivo mucus permeability and antibacterial efficacy to its native ciprofloxacin counterpart. International journal of pharmaceutics, 547(1-2), 368-376. doi: https://doi.org/10.1016/j.ijpharm.2018.06.017

Lee, J. W., Tay, T. R., Paddle, P., Richards, A. L., Pointon, L., Voortman, M., . . . Hew, M. (2018). Diagnosis of concomitant inducible laryngeal obstruction and asthma​​. Clinical & Experimental Allergy, 48(12), 1622-1630. doi: https://doi.org/10.1111/cea.13185

Yii, A. C. A., Tay, T.-R., Choo, X. N., Koh, M. S. Y., Tee, A. K. H., & Wang, D.-Y. (2018). Precision medicine in united airways disease: A “treatable traits” approach. Allergy, 73(10), 1964-1978. 10.1111/all.13496. doi: https://doi.org/10.1111/all.13496

Chotirmall, S. H., Dahlén, S.-E., Carlsten, C., Wong, W. S. F., Chung, K. F., Gosens, R., & Knight, D. A. (2018). International research collaboration: The way forward. Respirology, 23(7), 654-655. doi: https://doi.org/10.1111/resp.13327

Hiles, S. A., Harvey, E. S., McDonald, V. M., Peters, M., Bardin, P., Reynolds, P. N., Upham, J. W.,  Baraket M., Bhikoo Z., Bowden J., Brockway v, Chung, L. P., Cochrane B., Foxley G., Garrett J., Hew M., Jayaram L., Jenkins C., Katelaris C., Katsoulotos G., Koh, M. S., et al.  (2018). Working while unwell: Workplace impairment in people with severe asthma. Clinical & Experimental Allergy, 48(6), 650-662. doi: https://doi.org/10.1111/cea.13153

Lee, J., Ren Tay, T., Radhakrishna, N., Hore-Lacy, F., Mackay, A., Hoy, R., . . . Hew, M. (2018). Non-adherence in the era of severe asthma biologics and thermoplasty. European Respiratory Journal, 1701836. doi: https://doi.org/10.1183/13993003.01836-2017

Tay, C. K., Chua, Y. C., Takano, A., Chee, M. Y. M., Lim, W.-T., Lim, C., & Koh, M. S. (2018). Primary pulmonary lymphoepithelioma-like carcinoma in Singapore. Annals of thoracic medicine, 13(1), 30.​ doi: ​https://doi.org/10.4103/atm.atm_304_17

Chotirmall, S. H., & Koh, M. S. (2018). Letter from Singapore. Respirology, 23(2), 228-229. doi: https://doi.​org/10.1111/resp.13210

Please contact the TARIPH Secretariat​ if you have any TARIPH-related publications you would like to feature here. Publications listed here should demonstrate collaboration across Singapore or internationally. 


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