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Projects & Publications

Projects
TARIPH’s initial research programme focuses on three inter-related thematic areas. The flagship project addresses our population, while the secondary projects focus on patients and healthy people. TARIPH projects will generate evidence on the presentation, course and consequence of respiratory illness in our patients and the population at large, work that will benefit Singaporeans with respiratory diseases and the maintenance of lung health.

Flagship project​​​​

  • Phenotypes of respiratory disease: A translational approach and analysis of service impact

    This project focuses on delineating clinical, mechanistic, behavioural and cultural differences across a range of chronic inflammatory respiratory disease states in Singapore including asthma, COPD, bronchiectasis, allergic rhinitis and allergy to better understand important clinically relevant and academic questions in primary, secondary and tertiary care settings.
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Secondary projects​​​​​​​

  • United airways care in the community

    The united airways concept recognises that upper and lower airway diseases often coexist, but this relationship and the resultant multi-morbidity is not readily recognised. Hence, this project aims to establish the prevalence of asthma and rhinitis amongst patients cared for in the community (general practices and polyclinics), the interventions that will be needed to improve management, and the feasibility of allergy testing in the primary care setting.
  • Healthy lungs for our workforce: Occupational associated respiratory consequences

    This study aims to assess lung health in healthy individuals across a range of occupational and community settings that expose sub-populations to potential airway insults. The effect of lifestyle factors will also be assessed with the intention of understanding how best to preserve lung health as our workforce ages.
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Please email us at TARIPH@ntu.edu.sg​ if you would like to know more about any of these projects or contribute as a member and collaborator to our work.

Publications

Poh, T. Y., Ali, N. A. t. B. M., Mac Aogáin, M., Kathawala, M. H., Setyawati, M. I., Ng, K. W., & Chotirmall, S. H. (2018). Inhaled nanomaterials and the respiratory microbiome: clinical, immunological and toxicological perspectives. Particle and Fibre Toxicology, 15(1), 46. doi:10.1186/s12989-018-0282-0

Eguiluz‐Gracia, I., Tay, T. R., Hew, M., Escribese, M. M., Barber, D., O'hehir, R. E., & Torres, M. J. (2018). Recent developments and highlights in biomarkers in allergic diseases and asthma. Allergy. European Journal of Allergy and Clinical Immunology, 73(12), 2290-2305.

Mac Aogáin, M., Tiew, P. Y., Lim, A. Y. H., Low, T. B., Tan, G. L., Hassan, T., . . . Gwee, X. W. (2018). Distinct'Immuno-Allertypes' of Disease and High Frequencies of Sensitisation in Non-Cystic-Fibrosis Bronchiectasis. American Journal of Respiratory and Critical Care Medicine(ja).

McDonald, V. M., Hiles, S. A., Godbout, K., Harvey, E. S., Marks, G. B., Hew, M., Peters, M., Bardin, P. G., Reynolds, P. N., Upham, J. W., Baraket, M., Bhikoo, Z., Bowden, J., Brockway, B., Chung, L. P., Cochrane, B., Foxley, G., Garrett, J., Jayaram, L., Katelaris, C. J. C., Katsoulotos, G., Koh, M. S., et al. (2018). Treatable traits can be identified in a severe asthma registry and predict future exacerbations. Respirology.​

Yii, A. C., Soh, A. Z., Chee, C. B., Wang, Y. T., Yuan, J.-M., & Koh, W.-P. (2018). Asthma, Sinonasal Disease, and the Risk of Active Tuberculosis. The Journal of Allergy and Clinical Immunology: In Practice.

Ong, A. S. Q., Tan, A. H., Anantham, D., Sharma, K., Tan, S., Lapperre, T. S., . . . Koh, M. S. (2018). Impact of simulation training on performance and outcomes of endobronchial ultrasound-guided transbronchial needle aspiration performed by trainees in a tertiary academic hospital. Journal of thoracic disease, 10(9), 5621.

Mac Aogáin, M., Chandrasekaran, R., Lim, A. Y. H., Low, T. B., Tan, G. L., Hassan, T., . . . Chotirmall, S. H. (2018). Immunological corollary of the pulmonary mycobiome in bronchiectasis: the CAMEB study. European Respiratory Journal, 52(1), 1800766. doi:10.1183/13993003.00766-2018

Tay, T. R., Lee, J. W., & Hew, M. (2018). Diagnosis of severe asthma. Med J Aust, 209(2 Suppl), S3-S10.

Tran, T.-T., Vidaillac, C., Yu, H., Yong, V. F., Roizman, D., Chandrasekaran, R., . . . Abisheganaden, J. A. (2018). A new therapeutic avenue for bronchiectasis: dry powder inhaler of ciprofloxacin nanoplex exhibits superior ex vivo mucus permeability and antibacterial efficacy to its native ciprofloxacin counterpart. International journal of pharmaceutics, 547(1-2), 368-376.

Lee, J. W., Tay, T. R., Paddle, P., Richards, A. L., Pointon, L., Voortman, M., . . . Hew, M. (2018). Diagnosis of concomitant inducible laryngeal obstruction and asthma​​. Clinical & Experimental Allergy, 48(12), 1622-1630.

Yii, A. C. A., Tay, T.-R., Choo, X. N., Koh, M. S. Y., Tee, A. K. H., & Wang, D.-Y. (2018). Precision medicine in united airways disease: A “treatable traits” approach. Allergy, 73(10), 1964-1978. doi:doi:10.1111/all.13496

Chotirmall, S. H., Dahlén, S.-E., Carlsten, C., Wong, W. S. F., Chung, K. F., Gosens, R., & Knight, D. A. (2018). International research collaboration: The way forward. Respirology, 23(7), 654-655.

Hiles, S. A., Harvey, E. S., McDonald, V. M., Peters, M., Bardin, P., Reynolds, P. N., Upham, J. W.,  Baraket M., Bhikoo Z., Bowden J., Brockway v, Chung, L. P., Cochrane B., Foxley G., Garrett J., Hew M., Jayaram L., Jenkins C., Katelaris C., Katsoulotos G., Koh, M. S., et al.  (2018). Working while unwell: Workplace impairment in people with severe asthma. Clinical & Experimental Allergy, 48(6), 650-662.

Lee, J., Ren Tay, T., Radhakrishna, N., Hore-Lacy, F., Mackay, A., Hoy, R., . . . Hew, M. (2018). Non-adherence in the era of severe asthma biologics and thermoplasty. European Respiratory Journal, 1701836.

Tay, C. K., Chua, Y. C., Takano, A., Chee, M. Y. M., Lim, W.-T., Lim, C., & Koh, M. S. (2018). Primary pulmonary lymphoepithelioma-like carcinoma in Singapore. Annals of thoracic medicine, 13(1), 30.​

Chotirmall, S. H., & Koh, M. S. (2018). Letter from Singapore. Respirology, 23(2), 228-229. 

Please contact the TARIPH Secretariat​ if you have any TARIPH-related publications you would like to feature here. Publications listed here should demonstrate collaboration across Singapore or internationally. 

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