Professor Annabel Chen Shen-Hsing

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Professor Annabel Chen
PhD
Professor of Psychology, School of Social Sciences
Acting Director for Centre for Research and Development on Learning (CRADLE)
Nanyang Technological University

 

Email: annabelchen@ntu.edu.sg
Website: clinicalbrain.org

 

Staff List

  • Chiao-Yi WU, Post-doctoral Research Fellow (Staff under CRADLE, NTU)
  • Sagarika BHATTACHARJEE, Research Associate (Staff under SSS, NTU)
  • Hoki FUNG, Research Associate (Staff under HSS, NTU)
  • Alison CHEWProject Officer (Staff under HSS, NTU)
  • Su Ren GAN, Project Officer (Staff under HSS, NTU)
  • Marilyn YEO, Project Officer (Staff under HSS, NTU)
 
Biography
Dr Annabel Chen is a clinical neuropsychologist (licensed in Clinical Psychology, USA; Singapore Registry of Psychologists) and has worked with both adult and child populations. She received her Doctorate in Clinical Rehabilitation Psychology from Purdue University at Indianapolis. After completing her clinical psychology internship at West Virginia University School of Medicine, she went on to pursue a post-doctoral clinical residency in adult clinical neuropsychology at the Medical College of Wisconsin. She subsequently worked as a post-doctoral research affiliate at the Lucas MRS/I Center at Stanford University School of Medicine, and was an assistant professor at the National Taiwan University in the Graduate Clinical Psychology programme. She joined NTU as an associate professor and served as the Associate Chair for Research for the School of Humanities and Social Sciences before becoming a Deputy Director in CRADLE. She is currently Professor of Psychology in the School of Social Sciences and the Acting Director for CRADLE.

Research Interests

Dr Chen has a diverse research background, including animal drug studies, human neuropsychological research and cognitive rehabilitation. She has applied Positron Emission Tomography (PET) to study individuals with post-concussion sequelae from mild traumatic brain injury and olfaction in Alzheimer’s Disease, and has been involved in functional Magnetic Resonance Imaging (fMRI) research examining language processing, executive functions, and affective memory in healthy and clinical populations (e.g. stroke, anxiety, schizophrenia, dementia), as well as, assessing neural systems used in motor timing/timing perception in patients with Parkinson's Disease.  Her main research interests are to investigate underlying neural substrates involved in higher cognition in the cerebellum, as well as changes in cognitive processes in healthy aging and dementia through the application of neuroimaging techniques, such as fMRI, diffusion MRI,Transcranial Magnetic Stimulation (TMS), and most recently electroencephalography (EEG). The goal of her research is to apply these paradigms to study and to develop neuroimaging markers in the cerebro-cerebellar circuitry for clinical groups, and to further understand the processes of neurodevelopmental (e.g. schizophrenia, dyslexia, autism) and neurodegenerative (e.g. dementia, healthy aging) conditions that would be informative to evidence-based interventions.

The most recent research development in her lab, the Clinical Brain lab, is focusing on the Neuroscience of Learning and Education. In particular, their lab is investigating the neurophysiological changes in aging neuroscience for learning in language, memory and executive control networks. This allows development of neuromodulation techniques to optimize and/or enhance brain functions for learning. They are also developing research in understanding the effects of emotion on cognition and self-regulation with the use of neuroimaging.

Honours and Awards

Dr Chen received the Research Investment Fund Fellowship Award to pursue her doctorate at Purdue University (Indianapolis). She was awarded 10 prizes during graduate school, including the Henry Hécaen Neuropsychology Scholarship (Arthur Benton Scholarship Fund, APA Foundation, & Div. 40), the American Psychological Association Dissertation Research Award (APA Science Directorate), Outstanding Clinical Rehabilitation Psychology Doctoral Student Award and Outstanding Research Doctor of Philosophy Award in the School of Science. She also received a Magna Cum Laude Citation at the 37th Annual Scientific Meeting of the American Society of Neuroradiology. She received the Young Investigator Grant-in-aid Award by the National Science Council, Taiwan, and most recently she was awarded the Nanyang Award of Research Excellence.


Key Publications (*Corresponding Author; †Joint First Author)

 1. Lee S-H., Walker ZM, Hale JB, & Chen SHA* (2017). Frontal-subcortical circuitry in social attachment and relationships: a cross-sectional fMRI ale meta-analysis. Behavioural Brain Research, 325(Pt B): 177-130.

2. Archer JA, Lee A, Qiu A, & Chen SHA* (2017). Functional connectivity of resting-state, working memory and inhibition networks in perceived stress. Neurobiology of Stress, http://dx.doi.org/10.1016/j.ynstr.2017.01.002

3. Ng, H. B. T., Kao, K. L. C., Chan, Y. C., Chew, E., Chuang, K. H., & Chen, SHA* (2016). Modality specificity in the cerebro-cerebellar neurocircuitry during working memory. Behavioural Brain Research, 305, 164-173.

4. Sobczak-Edmans M, Ng HT, Chan YC, Chew E, Chuang KH & Chen SHA* (2016). Temporal dynamics of visual working memory. NeuroImage, 124, 1021-1030.

5. Archer, J. A., Lee, A., Qiu, A., & Chen SHA* (2016). A Comprehensive Analysis of Connectivity and Aging Over the Adult Life Span. Brain connectivity, 6(2), 169-185

6. Eng GK, Sim K, & Chen SHA* (2015). Meta-analytic investigations of structural grey matter, executive domain-related functional activations, and white matter diffusivity in obsessive compulsive disorder: An integrative review. Neuroscience & Biobehavioral Reviews. doi:10.1016/j.neubiorev.2015.03.002

7. E KH, Chen SHA*, Ho M-HR, Desmond JD (2014) A meta-analysis of cerebellar contributions to higher cognition from PET and fMRI studies, Human Brain Mapping, 35:593-615

8. Wu, C. Y., Ho, M. H. R., & Chen SHA* (2012). A meta-analysis of fMRI studies on Chinese orthographic, phonological, and semantic processing. NeuroImage, 63(1), 381-391.

9. Matsuo K, Chen SHA†, Liu C-M, Liu C-C, Hwang, T-J, Hsieh MH, Chien YL, Hwu H-G, Tseng W-Y (2013) Stable signatures of schizophrenia in the cortical-subcortical-cerebellar network using fMRI of verbal working memory, Schizophrenia Research. DOI: 10.1016/j.schres.2013.10.028

10. Ta AT, Huang S-E, Chiu M-J, Hua M-S, Tseng W-YI, *Chen S-HA, and *Qiu A (2011). Age-related vulnerabilities along the hippocampal longitudinal axis. Human Brain Mapping, 33(10), 2415–2427, DOI: 10.1002/hbm.21364