Associate Prof Chew Sing Yian

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Associate Professor Chew Sing Yian
PhD
Associate Professor, School of Chemical & Biomedical Engineering,
Associate Professor, Lee Kong Chian School of Medicine,
Nanyang Technological University
Email: sychew@ntu.edu.sg
Website: http://www.ntu.edu.sg/home/sychew

 
 
Laboratory Staff
  • ​Dr Coline PINESE, PhD, Research Fellow
  • Dr Ulla MILBRETA, PhD, Research Fellow
  • Dr CHOOI Wai Hon, PhD, Research Fellow
  • NGUYEN Lan Huong, Project Officer​
  • PENG Yanfen, Project Officer​
  • William ONG, Ph.D. student
  • LIN Junquan, PhD student
  • ZHANG Na, PhD student
  • CHIN Jiah Shin, PhD student

For more information: http://www.ntu.edu.sg/home/sychew/the-team.html

Introduction
Associate Professor Chew Sing Yian is an Associate Professor at the Lee Kong Chian School of Medicine (LKCMedicine) and the School of Chemical & Biomedical Engineering (SCBE), Nanyang Technological University (NTU), Singapore. Assoc Prof Chew obtained her PhD at Johns Hopkins University in 2006, under the sponsorship of the NTU Overseas Scholarship. Thereafter, she joined SCBE as Assistant Professor later in the same year. In 2012, Assoc Prof Chew received her tenure and was promoted to Associate Professor in SCBE. In March 2014, Assoc Prof Chew received joint appointment with LKCMedicine. Starting July 2014, she serves as Associate Chair of Research in SCBE.
Assoc Prof Chew is known for her contributions to the field of regenerative medicine and stem cell engineering. Her research interests lie in understanding the combined effects of nanotopography and biochemical signalling in directing cell fate. Specifically, her lab engineers nanofiber platforms for long-term delivery of biochemicals. Currently, Assoc Prof Chew’s work focuses on scaffold-mediated delivery of small non-coding RNAs for long-term gene silencing applications. These biofunctional platforms are used for understanding and directing neural tissue regeneration post-traumatic injuries, stem cell fate and host-implant integration.
Since joining NTU, Assoc Prof Chew has continued to embark on scientific learning and exchanges by serving as visiting scholar/professor to INSERM (U698 and U791); University of Paris 13; University of Nantes; Jinan University in Guangzhou, China; and Wyss Institute at Harvard. She also serves as the editorial board member in Drug Delivery and Translational Research, a new official journal of the highly regarded Controlled Release Society. Her professional experience also includes evaluating research grants for local and international funding bodies including the Research Grant Council of Hong Kong.
Research
The Chew laboratory engineers bio-functional micro- and nano-structured scaffolds to understand and direct cellular behavior. They use combinatorial approaches involving substrate topography/compliance and biochemical cues to mediate tissue regeneration and host-implant integration.
Their works range from fundamental science to scaffold, drug/gene delivery technology development; and translational research. Currently, they focus on scaffold-mediated gene-silencing approaches to understand and direct neural tissue regeneration, stem cell differentiation and host-implant integration.
Their main objective is to provide improved platforms for better understanding and control over cell fate for regenerative medicine.
The Cell & Tissue Engineering Lab - Engineering bioinspired drug/gene-delivery scaffolds for directing cell fate.research1.jpgPublication
  1. U Milbreta, N L Huong, H J Diao, J Q Lin, W T Wu, C-Y Sun, J Wang and S Y Chew, 'Three-dimensional nanofiber hybrid scaffold directs and enhances axonal regeneration after spinal cord injury', ACS Biomaterials Science & Engineering, 2 (8), pp. 1319-1329, doi: 10.1021/acsbiomaterials.6b00248.

  2. H J Diao, K Wang, H Y Long, M F Wang, S Y Chew, 'Highly Fluorescent and Photostable Polymeric Nanofibers as Scaffolds for Cell Interfacing and Long-Term Tracking', Advanced Healthcare Materials, 5 (5), pp. 529-533, doi: 10.1002/adhm.201500693.

  3. H J Diao, W C Low, R Q Lu, S Y Chew, 'Topographical effects on fiber-mediated microRNA delivery to control oligodendroglial precursor cells development', Biomaterials, 70, pp. 105-114, doi: 10.1016/j.biomaterials.2015.08.029.

  4. S Y Chew, 'MicroRNAs in tissue engineering and regenerative medicine', Advanced Drug Delivery Reviews, 88, pp. 1-2, doi: 10.1016/j.addr.2015.07.001.

  5. L H Nguyen, H J Diao and S Y Chew, 'microRNAs and their potential therapeutic applications in neural tissue engineering', Advanced Drug Delivery Reviews, 88, pp. 53-66, doi: 10.1016/j.addr.2015.05.007.

  6. H J Diao, W C Low, U Milberta, Q R Lu and S Y Chew, 'Nanofiber-mediated microRNA delivery to enhance differentiation and maturation of oligodendroglial precursor cells', Journal of Controlled Release, doi: 10.1016/j.jconrel.2015.03.005.

  7. W W Yau, H Long, N C Gauthier, J K Chan and S Y Chew, 'The effects of nanofiber diameter and orientation on siRNA uptake and gene silencing', Biomaterials, 37C, pp. 94-106. doi:  10.1016/j.biomaterials.2014.10.003.

  8. X Jiang, R Mi, A Hoke, S Y Chew, 'Nanofibrous nerve conduit-enhanced peripheral nerve regeneration', J Tissue Eng Regen Med., 8(5), pp. 377-85, 2014. doi: 10.1002/term.1531.

  9. W C Low, P Rujitanaroj, D K Lee, P B Messersmith, L W Stanton, E Goh and S Y Chew, 'Nanofibrous scaffold-mediated REST knockdown to enhance neuronal differentiation of stem cells', Biomaterials, 34 (14), pp. 3581-3590. doi:10.1016/j.biomaterials.2013.01.093.

  10. P Rujitanaroj, B Jao, J Yang, J Wang, J M Anderson and S Y Chew, ‘Controlling fibrous capsule formation through long-term down-regulation of collagen type I (COL1A1) expression by nanofiber-mediated gene silencing’, Acta Biomaterialia, 9 (1), p. 4513-4524. doi: 10.1016/j.actbio.2012.09029.