Assistant Prof Juliana Chan

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Nanyang Assistant Professor Juliana M. Chan
PhD 
Email: julianachan@ntu.edu.sg 
Principal Investigator, Nanomedicine and Tissue Engineering​ Laboratory

Introduction

Assistant Professor Juliana Chan is a Nanyang Assistant Professor (NAP) based at the School of Chemical and Biomedical Engineering (SCBE) and Lee Kong Chian School of Medicine. She received a PhD in Biology from the Massachusetts Institute of Technology (MIT), USA; and a MA, BA in Natural Sciences from the University of Cambridge, UK. She completed a post-doctoral fellowship at the Department of Biological Engineering at MIT, USA, before she became a research fellow at the Agency for Science, Technology and Research (A*STAR), Singapore.

Asst Prof Chan’s scientific work has been featured by the BBC Health, Singapore Straits Times, and the South China Morning Post. She has published three international patents, one of which has been licensed for commercialisation by a biotech company in Cambridge, MA.

In 2010, she won the Singapore Women’s Weekly Great Women Of Our Time Award (Science & Technology), and in 2011 she was one of the two national fellows of the L’Oréal-UNESCO For Women in Science Fellowships. She was awarded in 2013 the elite Nanyang Assistant Professorship (NAP) award, which provides S$1 million in start-up funds towards her laboratory at LKCMedicine. Dr Chan's also won in 2013 the Singapore Youth Award, the highest accolade for youth, for her scientific research and contributions to the science community in Singapore.

Asst Prof Chan has a strong interest in science communications. In 2011, she founded Asian Scientist Magazine, a science and technology news portal which in 2013 received a high six-figure investment from World Scientific Publishing Company, Singapore's largest science and technology publisher. Asst Prof Chan also writes for publications such as Nature Biotechnology and she is an editorial board member of INNOVATION Magazine, a joint research magazine produced by NUS, NTU, and SUTD. She sits on the board of directors of two non-profit charity organisations in Singapore.

 

Research Area

The Laboratory of Nanomedicine and Tissue Engineering will focus on three areas of research:

  1. Nanomedicine: They will design novel targeted nanoparticle platforms for drug delivery with applications in cancer and cardiovascular disease. Their previous research involved a nanoparticle technology platform called "nanoburrs” ref: Chan et al. PNAS (2010) and Chan et al. PNAS (2011).
  2. Tissue engineering and microfluidics: They will grow biological tissues in vitro that mimic human organs using microfluidic devices. These de novo grown tissue may combine large blood capillary networks in co-culture with stromal cells towards the engineering of higher order tissue.
  3. Skin biology: They will focus on skin biology applications that involve targeted nanoparticle-based drug delivery of biologics and small molecules, and artificial skin models.

 

 

 LKCMedicine Research Spotlight

 
 

Key Publications
  1. Chan JM, Zervantonakis IK, Rimchala T, Polacheck WT, Whisler J, Kamm RD. Engineering of in vitro 3D capillary beds by self-directed angiogenic sprouting. PLoS ONE (2012) 7(12): e50582. Highlighted in Lab on a Chip.
  2. Xiao Z, Levy-Nissenbaum E, Alexis F, Lupták A, Teply BA, Chan JM, Shi J, Digga E, Cheng J, Langer R, Farokhzad OC. Engineering of Targeted Nanoparticles for Cancer Therapy Using Internalizing Aptamers Isolated by Cell-Uptake Selection. ACS Nano (2012) 6(1):696-704.
  3. Wong K, Chan JM, Kamm RD, Tien J. Microfluidic Models of Vascular Functions. Annual Review in Biomedical Engineering (2012) 14:205-30.
  4. Chan JM, Rhee JW, Drum CL, Bronson RT, Golomb G, Langer R, Farokhzad OC. In vivo prevention of arterial restenosis with paclitaxel-encapsulated targeted lipid-polymeric nanoparticles. Proc Natl Acad Sci U S A (2011) 108(48):19347-52. Highlighted in South China Morning Post.
  5. Gao W, Chan JM, Farokhzad OC. pH-responsive nanoparticles for drug delivery. Mol Pharm (2010) 7(6):1913-20.
  6. Chan JM, Zhang L, Tong R, Ghosh D, Gao W, et al. Spatiotemporal Controlled Delivery of Nanoparticles to Vasculature. Proc Natl Acad Sci U S A. (2010) 107(5):2213-8. Highlighted in BBC HealthThe IndependentScience DailyMedical News TodayNano TodayThe Singapore Straits Ti​mes​
  7. Chan JM, Valencia PM, Zhang L, Langer R, Farokhzad OC. Polymeric nanoparticles for drug delivery. Methods Mol Biol. (2009) 624:163-75. 
  8. Chan JM, Zhang L, Yuet KP, Liao G, Rhee JW, Langer R, et al. PLGA-lecithin-PEG core-shell nanoparticles for controlled drug delivery. Biomaterials. (2009) 30(8):1627-34. 
  9. Nguyen DN, Green JJ, Chan JM, Langer R, Anderson DG. Polymeric Materials for Gene Delivery and DNA Vaccination. Advanced Materials. (2009) 21(8):847-67. 
  10. Zhang L, Chan JM, Gu FX, Rhee J-W, Wang AZ, et al. Self-Assembled Lipid-Polymer Hybrid Nanoparticles: A Robust Drug Delivery Platform. ACS Nano. (2008) 2(8):1696-702.

 

Patents

  1. Farokhzad OC, Salvador-Morales C, Gao W, Zhang L, Chan JM, Langer RS. Particles with multiple functionalized surface domains. Patent Publication No.: US 2012/0156135
  2. Alexis F, Zhang L, Chan J, Basto P, Levy-Nissembaum E, Langer R, Farokhzad OC. Poly (Amino Acid)-Targeted Drug Delivery. Patent Publication No.: US 2009/0074828 Patent licensed to BIND Biosciences, Cambridge, MA.
  3. Chan JM, Langer R, Farokhzad OC. Endothelial Basement Membrane Targeting Peptide Ligands for Nanoparticle Delivery of Therapeutic Agents. Patent Publication No.: US 2011/0143993