After completing his undergraduate degree in Bern, Switzerland, Dr Oliver Dreesen worked as a research technician at the Pasteur Institute in Paris, the University of California, San Diego and Lonza AG in Visp, Switzerland. As a graduate student, Dr Dreesen moved to the laboratory of Professor George A. M. Cross at the Rockefeller University in New York, where he studied the structure and function of telomeres and telomerase in Trypanosoma brucei. T. brucei is a protozoan parasite and the causative agent of African sleeping sickness. His Ph.D. research revealed that growth and breakage of telomeric repeats play an important role in regulating host immune evasion (antigenic variation) in trypanosomes. In 2009, Dr Dreesen joined the laboratory of Professor Alan Colman at the Institute of Medical Biology in Singapore to study telomeres during cellular reprogramming and in rare genetic human diseases. Currently, Dr Dreesen is further investigating the role of telomere dysfunction and senescence in human ageing and disease.
Chojnowski A, Ong PF, Mutalif RA, Navasankari R, Dutta B, Yang H, Sze NSK, Colman A, Burke B, Stewart CL* and Dreesen O* (2015). Progerin reduces LAP2α:telomere association in Hutchinson-Gilford progeria syndrome.
eLife August 27;4 10.7554 *co-corresponding author
Chojnowski A, Ong PF, Dreesen O* (2014). Nuclear lamina remodeling and its implications for human disease. Cell & Tissue Research December 24th
Dreesen O*, Chojnowski A, Ong PF, Zhao TY, Common JE, Lunny D, Lane EB, Lee SJ, Vardy LA, Stewart CL, Colman A* (2013). Consequences of Lamin B1 fluctuations on cellular proliferation and senescence. Journal of Cell Biology March 4; 200(5): 605-17
*co-cor responding author
Dreesen O*, Ong PF, Chojnowski A, Colman A* (2013). The contrasting roles of lamin B1 in cellular aging and human disease. Nucleus 4:4,1-8; July / August
Pomp O, Dreesen O, Leong D, Tan T, Meller-Pomp O, Colman A (2011). Unexpected X-chromosome skewing during culture and reprogramming of human somatic cells can be alleviated by exogenous telomerase. Cell Stem Cell August 5;9(2):156-65
Colman A* and Dreesen O* (2009).Pluripotent stem cells and disease modeling. Cell Stem Cell September 4;5(3)244-7
Boothroyd CE*, Dreesen O*, Leonova T, Ly KI, Figueiredo LM, Cross GAM, Papavasiliou FN (2009). A yeast-endonuclease-generated DNA break induces antigenic switching in Trypanosoma brucei. Nature May 14; 459(7244):278-81
*these two authors contributed equally to this work
Dreesen O, Li B and Cross GAM (2007). Telomere structure and function in trypanosomes: a proposal. Nature Reviews Microbiology January 5 (1): 70-75
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list of publications.