Professor Sven Pettersson
Professor of Metabolic Disorders
Principal Investigator, Microbiota Host Interactions, Nutrigenomics & Metabolism Laboratory
- Parag Kundu, Senior Research Fellow
- Lee Hae Ung, Senior Research Fellow
- Kim Hye Jin, Senior Research Fellow
- Ruchi Agrawal, Research Fellow
- Maisha Reza, PhD, Assistant/Personal Assistant
- Alicia Kang, Research Assistant/Personal Assistant
- Katherine Martin Ann, PhD Student
- Xing Yuli, PhD Student
Germ Free Facility Team Members
- Elma Llanto Faylon, Research Assistant, Veterinarian
- Maryann Ang, Research Assistant
- Norhashimah Binte Sulaiman, Research Assistant
- Teo Kok Huan, Research Assistant
Sven Pettersson, MD, PhD, is a cell biologist focusing on microbiome
mediated mechanisms regulating mammalian host physiology. Ongoing projects seek
to decipher microbiome mediated signalling pathways and metabolites that support
cell metabolism relevant to neurons and muscle cells. He joined the Lee Kong
Chain School of Medicine in 2014 as Professor of Metabolic Disease and was
concurrently appointed Scientific Director of the School’s Germ-Free facility
in Singapore. In 2015, he was appointed Deputy Director of Cluster 2 at the Centre
of Microbial Excellence, SCELSE. The same year, he was also appointed Senior
Research Fellow at the Canadian Institute for Advanced Science (CIFAR).
Pettersson believes that microbes are key components in maintaining body
functions relevant to health, a paradigm shift from the perception that
microbes are only harmful to human health. Prof Pettersson is a strong proponent of the holobiont concept, which
considers human beings as a composite of several different microorganisms that
together with the mammalian genome collectively determine body, mind and
function i.e., your individuality. He is highly recognised for discovering a
link between the microbial communities in our gut and the development and
function of the brain. His finding that gut microbes could change behaviour and
affect key neuronal signalling pathways in animal models has provided important
new insights in neurobiological research in CNS and lately also in ENS. While
working mostly in animal models, his team also has initiated collaborations
with healthcare workers working in areas of neurodegenerative diseases and
healthy ageing. Ultimately, Prof
Pettersson hopes to identify better diagnostics and biomarkers that sustain
health, prevent frailty and cognitive decline.
- Thion MS, Low D, Silvin A, Chen J, Grisel P, Schulte-Schrepping J,
Blecher R, Ulas T, Squarzoni P, Hoeffel G, Coulpier F, Siopi E, David FS,
Scholz C, Shihui F, Lum J, Amoyo AA, Larbi A, Poidinger M, Buttgereit A, Lledo
PM, Greter M, Chan JKY, Amit I, Beyer M, Schultz JL, Schlitzer A, Pettersson
S, Ginhoux F, Garel S. (2017). Microbiome influences prenatal and adult microglia in a sex-specific
Manner. Cell. 172:1-17.
P, Blache E, Elinav E, Pettersson S.
gut microbiome: the evolving inner self. Cell. 171(7):1481-1493.
- Korecka A, Dona A,
Lahiri S, Tett AJ, Al-Asmakh M, Braniste V, D’Arienzo R, Abbaspour A, Reichardt
N, Fujii-Kuriyama Y, Rafter J, Narbad A, Holmes E, Nicholson J, Arulampalam V, Sven Pettersson. (2016). Bidirectional
communication between the Aryl hydrocarbon Receptor (AhR) and the microbiome
tunes host metabolism. NPJ Biofilms Microbiome. 2: 16014.
- Kundu P, Genander M, Strååt K, Classon J, Ridgway
RA, Tan EH, Björk J, Martling A, van Es J, Sansom OJ, Clevers H, Pettersson S, Frisén J. (2015). An EphB signaling pathway is associated with
intestinal tumor initiation and growth. Sci Transl
Med. 7(281): 281ra44.
- Kabouridis PS, Lasrado R, McCallum S, Song HC, Snippert
HG, Clevers H, Pettersson S, Pachnis
V. (2015). Microbiota controls the homeostasis of glial cells in the gut lamina
propria. Neuron. 85(2): 289-295.
- Braniste V, Al-Asmakh M, Kowal C, Anuar F, Abbaspour
A, Toth M, Korecka A, Bakocevic N, Ng LG, Kundu P, Gulyas B, Halldin C, Hultenby
K, Nilsson H, Hebert H, Volpe BT, Diamond B, Pettersson S. (2014). The indigenous gut microbiota regulate permeability of the blood-brain
barrier in mice. Sci Transl Med. 6(266):
- Kundu P, Pettersson S.
(2014). Immunology: Mammalian watchdog targets bacteria. Nature.
- Kundu P, Ling TW, Li Y, D’Arienzo R, Bunte RM,
Berger T, Arulampalam V, Chambon P, Mak TW, Wahli W, Pettersson S. (2013). Absence of intestinal PPARgamma aggravates acute
infectious colitis in mice through a Lipocalin-2 dependent pathway. PloS
- Nicholson JK, Holmes E, Kinross J, Burcelin R,
Gibson G, Jia W, Pettersson S.
(2012). Host-gut microbiota metabolic interactions. Science. 336(6086):1262-1267.
- Diaz Heijtz R, Wang S, Anuar F, Qian Y,
Björkholm B, Samuelsson A, Hibberd ML, Forssberg H, Pettersson S. (2011). Normal gut microbiota modulates brain development
and behavior. Proc Natl Acad Sci U.S.A.