Assistant Professor Wang Xiaomeng
Assistant Professor of Molecular Medicine
Principal Investigator, Vascular Biology Laboratory
- Dr Madhura Kulkani, PhD, Senior Research Fellow
- Dr Jonathan Lim Chee Woei, PhD, Research Fellow
- Dr Kwan Yuet Ping, PhD, Research Fellow
- Ng Xuan Rui, Research Assistant
- Michelle Tan Siying, Research Assistant
- Chia Rui Ning, PhD student
- Liu Chenghao, PhD student
- Ho Sze Yuan, PhD student
- Lim Seok Ting, PhD student
- Hannah L Murray, PhD student
Assistant Professor Wang Xiaomeng is an Assistant Professor at the Lee Kong Chian School of Medicine, Nanyang Technological University. Prior to this appointment, Asst Prof Wang spent her scientific career at the world-renowned University College London, United Kingdom (UK). Asst Prof Wang obtained her BSc. in Biology at Beijing Normal University, China and her PhD in Genetics at Newcastle University, UK. She then undertook post-doctoral training at Manchester University, UK.
Asst Prof Wang is interested in the role of TGFβ signalling in development and under disease conditions. Her earlier work demonstrated that type IV collagen not only function as an affinity matrix for binding and immobilizing TGFβ family growth factor, Decapentaplegic (Dpp), but also regulates its signalling during Drosophila development. Her recent study led to the identification of another novel regulator of TGFβ signalling, Leucine rich alpha 2 glycoprotin 1 (Lrg1). This work revealed for the first time the function and molecular mechanism of Lrg1 regulated TGFβ signalling in pathological angiogenesis and raised the intriguing possibility of targeting Lrg1 as a novel treatment for diseases such as diabetic vascular complications, cancer, atherosclerosis and rheumatoid arthritis. Both studies have been published in Nature as an article.
A healthy, intact vasculature is central to the normal organ and tissue function. Abnormal quantity and quality of blood vessels will cause severe complications. The focus of the Wang lab is to gain novel insights into the molecular and cellular mechanisms that modulate, inhibit and promote blood vessel formation. The goal is to develop novel therapeutic approaches targeting angiogenesis, a key feature shared by over 70 major health conditions affecting more than one billion people worldwide.
Research in the Wang lab is focused on the following aspects:
1) Unravel the basic cellular principles and the molecular control of differential angiogenic responses in diabetic vascular complications.
2) Investigate the impact of Lrg1 regulated TGFβ signalling in different types of diabetic vascular complications as well as in other angiogenesis-related diseases.
3) Develop novel therapeutic approaches targeting angiogenesis for the treatment of angiogenesis-related diseases.
4) Study the role of Lrg1 in TGFβ regulated fibrotic diseases.
- Wang, X., Harris, R.E., Bayston, L.J. and Ashe, H.L. (2008). Type IV collagens regulate BMP signalling in Drosophila. Nature 455: 72-77.
- McKenzie JAG, Fruttiger M, Abraham S, Lange CA, Stone J, Gandhi P, Wang X, Bainbridge J, Moss SE, Greenwood J. Apelin is required for non-neovascular remodeling in the retina. Am J Pathol. 2012 Jan 180(1): 399-409.
- Wang X, Abraham S, McKenzie JAG, Jeffs N, Swire M, Lange CAK, Luhmann U, Bainbridge J, Zhai Z, Arthur H, Moss SE, Greenwood J. Lrg1 promotes angiogenesis by modulating endothelial TGFβ signaling. Nature. 2013 July 18; 499 (7458):306-311.
- Pek SL, Tavintharan S, Wang X, Chi Lim S, Woon K, Ying Yeoh L, Ng X, Liu J, Fang Sum C. Elevation of a novel angiogenic factor, Leucine-Rich-α2-Glycoprotein (LRG1), is associated with arterial stiffness, endothelial dysfunction and Peripheral Arterial Disease in patients with Type 2 Diabetes. J Clin Endocrinol Metab. 2015 Jan 30:jc20143855.
- Song WH, Fhu CW, Ang KW, Liu CH, Nurul ABJ, Lio CS, Abraham S, Moss SE, Greenwood J, Hong WJ, Wang X. The foetal mouse metatarsal bone explant as a model of angiogenesis. Nature Protocols. In press
- Treatment of vasculoproliferative conditions
Treatment of Cancer
- Priority Date: 04/09/2009
- PCT number: PCT/GB2010/001681
- Publication No: WO2011027129
- Publication date: 10/03/201
- Priority Date: 09/03/2012
- PCT number: PCT/GB2013/050580