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Balázs Gulyás

Balazs Gulyas-01 (Custom).jpg
 
Professor Balázs Gulyás
MD, PhD
Professor of Translational Neuroscience and
President's Chair in Translational Neuroscience
Scientific Director of the Neuroscience and Mental Health Research Programme
Principal Investigator, Translational Neuroscience Laboratory​

 

Team

  • ​Dr Parasuraman Padmanabhan, Deputy Director
  • Dr Sundramurthy Kumar, Project Manager 
  • Dr Vimalan Vijayaragavan, MR Physicist
  • Dr Krishna Ghosh Kanta, Senior Research Fellow
  • Dr Lena Lim Hui Xiang. Research Fellow
  • Mr Thein Than Htike, Research Associate
  • Mr Dilip Kumar, Research Associate
  • Ms Ellen Partington Victoreen, Senior Assistant Manager, Radiography
  • Mr Vincent Tan Teow Hwee, Radiographer
  • Mr Sachin Mishra, Engineer
  • Ms Najwa Binte Said Nasir Talib, Research Assistant
  • Mr Xia Yang, PhD Student
  • Ms Cassia Low Man Ting, PhD Student
  • Mr Satnam Singh, MSc Student
  • Mr Musafar Gani, MSc Student
  • Mr Pandarinathan Ganesh, MSc Student
  • Ms Aishwarya Sanjeev Hattiholi, Attachment MSc Student, VIT, India
  • Ms Thulasi Priyadharshini, Attachment MSc Student, PSG College, Coimbatore
  • Ms Tiyasha Patnaik, Attachment BTech Student, VIT, India
  • Ms Mathangi, BSc CN Yang Scholar’s Student



Laboratory Alumni

  • Dr Wang Zhimin, Research Fellow
  • Ms Siti Nabilah Hamidon, Research Assistant

NTU Attachment students for coursework (Master Degree)
  • Ms Anu Maashaa

Final year attachment students (International)
  • Mr Anand Mohan
  • Mr Fredin AS Givo
  • Mr Gibin Punnoose
  • Mr Libin C Mathew
  • Mr Sikkandhar Musafargani
  • Ms Induja 
  • Mr Satnam Singh
  • Ms Roopa Ravichandar
  • Mr Ajay Kumar
  • Mr Sachin Mishra
  • Ms Anu Maashaa
  • Mr Pandarinathan Ganesh 
  • Ms Rukmani Thiruppathi 
  • Mr Sakthivel Srinivasan

Attachment students (From Junior College)
  • Ms Santhanakrishnan Priyadharshini
  • Mr Ng Ri Chi 
  • Ms Narayanan Madhumita
  • Mr Murukeshan Jishnu
  • Ms Priya Darshini Balavela 
  • Ms Malena Ramnath, Singapore American School
  • Ms Patankar Saylee Nilesh, Raffles Institute


CN Yang Scholar’s Programme student
  • Ms Chen Jiahui

URECA Student
  • ​Mr GOH Zheng Cong

Introduction

Professor Balázs Gulyás is Professor of Translational Neuroscience at the Lee Kong Chian School of Medicine, Nanyang Technological University (NTU), Singapore. Prior to this appointment in 2013, he spent most of his scientific career at the Karolinska Institutet, Stockholm, Sweden, where he is still a Professor in the Department for Psychiatry, Division of Clinical Neuroscience. 

After obtaining his MD degree at Semmelweis University, Budapest, Hungary, in 1981, and pursuing further undergraduate studies in physics and philosophy in Budapest, Cambridge and Leuven (BA and MA: 1982 and 1984), he made his PhD in neuroscience at the Catholic University of Leuven, Belgium, in 1988, followed by his postdoctoral studies at the Department of Clinical Neurophysiology of the Karolinska Institutet and at the Department of Experimental Psychology at the University of Oxford, UK.

Prof Gulyás has made pioneering contributions to the field of functional brain mapping with positron emission tomography (PET), in particular to the localisation of cortical areas in the human brain related to visual perceptual functions, visual memory and imagery, olfactory and pheromone-sense functions. More recently, his research focused on molecular neuroimaging with PET, focusing on neurological and psychiatric diseases and their “humanised” murine and primate animal disease models. At Singapore’s newest medical school, the Lee Kong Chian School of Medicine, he – as one of the founding professors of the School – is the scientific director of the “Neuroscience and Mental Health Theme”. He is also the Director of the Cognitive Neuroimaging Centre (CoNiC) of NTU (conic.ntu.edu.sg).

Prof Gulyás​ has published thirteen books, authored over thirty-five book chapters and contributed to more than 200 research papers in peer reviewed scientific journals. He is a member of, among others, the Academia Europaea, the Hungarian Academy of Sciences and the Royal Belgian Academy of Medical Sciences. Concurrent with his appointments at LKCMedicine in Singapore and the Karolinska Institutet in Stockholm, he is an Honorary Professor at the Division of Brain Sciences, Department of Medicine, Imperial College London. 

Research Focus
The main research focus of the Translational Neuroscience Laboratory is (1) to identify early disease mechanisms and, based on that, early disease biomarkers for early prediction and diagnosis of pathological ageing, neurological and psychiatric diseases; (2) to develop imaging probes, including multimodal and molecular/nuclear imaging probes; and (3) to use neuroimaging approaches for exploring normal and pathological brain functions.

Research Facilities
The Translational Neuroscience Laboratory have created a Translational Neurobiology Platform (TNP) and an Imaging Probe Development Platform (IPDP) in the Experimental Medicine Building of our School, but its activities include close collaborations with other core facilities at LKCMedicine (i.e. the animal facility with murine and marmoset models or the human brain bank and neuropathological laboratory) as well as with other academic, research and clinical institutions in Singapore (e.g. DSO, IMH, NNI).

In addition, as Prof Gulyás is the Director of NTU’s Cognitive Neuroimaging Centre​ (CoNiC) and several members of the group are also with CoNiC, the Group is heavily involved in neuroimaging activities.












Research Projects

At present, the Translational Neuroscience Laboratory is engaged with in-house projects as well as joint projects realised with colleagues within or outside NTU, including the following ones:

  1. Molecular imaging of murine gut biota models (with Professor Sven Pettersson, LKCMedicine);
  2. Cord-line pluripotent stem cell based dopaminergic cell transplantation in Parkinson’s disease (with Professor Kah Leong Lim, NNI and NUS);
  3. In Vivo Quantitative Analysis with PET of the Dopamine Transporter in the KI-G2019S LRRK2 mice with [18F]FE-PE2I (with A/Prof Zeng Li, NNI);
  4. In vivo imaging on microglial up-regulation, visualised by PET measurements using the TSPO radioligand [11C]PBR28, in a rodent percussion TBI model (with A/Prof Lu Jia, DSO);
  5. In vivo PET imaging of acute TBI and PTSD in an open blast NHP TBI model (with A/Prof Lu Jia, DSO);
  6. Exploration of Neuroprotective Effects of Functionalized Hydrophilic Carbon Clusters: Targeted Therapy of Traumatic Brain Injury (TBI) Pilot experiment using a closed blast rodent TBI model (with Professors Jan Carlstedt-Duke, NTU, Thomas Kent, Baylor College of Medicine, Texas, Jim Tour, Rice University, Texas, Lu Jia, DSO);
  7. Exploration of Neuroprotective Effects of Functionalized Hydrophilic Carbon Clusters: Targeted Therapy of Traumatic Brain Injury (TBI) Pilot experiment using an open blast rodent TBI model (with Professors Jan Carlstedt-Duke, NTU, Thomas Kent, Baylor College of Medicine, Texas, Jim Tour, Rice University, Texas, Lu Jia, DSO);
  8. Nanoparticles as potential imaging agents (with A/Profs Krisztián Szigeti, Semmelweis University Budapest and Domokos Máté, CROMed Research Ltd, Budapest);
  9. Development of Beta Cell Mass (BCM) radioligands (with Professor James Best and Asst.Prof. Yusuf Ali, LKCMedicine and Professor Christer Halldin, Karolinska Institute Stockholm);
  10. Establishment of the novel TSPO radioligand 18F-BCPP-PE (with Asst.Prof. Anna Barron, LKCMedicine, and Professors Christer Halldin, Karolinska Institute, Stockholm, and Hideo Tsukada, Hamamatsu Photonics PET Centre, Japan);
  11. Microfluidic radiochemistry projects (with Professors Lam Yee Cheong, MAE, NTU; Tan Choon Hong, SPMS, NTU; Lim Yee Hwee, ICES, ASTAR; Christer Halldin, Karolinska Institute, Stockholm; Uno Zetterberg, GE Medical Systems Uppsala);
  12. A new Parkinson Disease candidate drug development (with Professor Yoon Ho-Sup, SBS, NTU);
  13. Bifunctional fluorescent/Raman nanoprobes for the early detection of beta amyloid (with A/Prof Murukeshan Vadakke Matham, MAE, NTU);
  14. Novel multimodal imaging probes for misfolded protein imaging (In-House Project, Lead: Dr. Parasuraman Padmanabhan);
  15. Development of curcumin based probe for tau imaging (In-House Project, Lead: Dr. Krisha Gosh Kanta);
  16. 68Ga-based radiochemistry projects (In-House Project, Lead: Dr Yang Changtong).
Research projects related to the activities of the Cognitive Neuroimaging Centre can be found here.


Selected Publications
Szigeti K, Hegedüs N, …, Gulyás B, et al. (2018). Thallium Labeled Citrate-Coated Prussian Blue Nanoparticles as Potential Imaging Agent. Contrast Media and Molecular Imaging. 2018(2023604).

Odano I, Varrone A, …, Gulyás B, et al. (2017). Simplified estimation of binding parameters based onimage-derived reference tissue models for dopamine transporter bindings innon-human primates using [18F]FE-PE2I and PET. American Journal of Nuclear Medicine and Molecular Imaging. 7(6):246-254.

Yang CT, Ghosh KK, …, Gulyás B. (2017). PET probes for imaging pancreatic islet cells.​ Clinical and Translational Imaging. 5(6):507-523.

Lim J, Chin R, …, Gulyás B, et al. (2017). Elucidation of shared and specific white matter findings underlying psychopathology clusters in schizophrenia.  Asian Journal of Psychiatry. 30:144-151.

Narayanan K, Mishra S, …, Gulyás B, et al. (2017). Engineering Concepts in Stem Cell Research. Biotechnology Journal. 12(12).

Thiruppathi R, Mishra S, …, Gulyás B. (2017). Nanoparticle Functionalization and Its Potentials forMolecular Imaging. Advanced Science. 4(3):1600279.

Sikkandhar MG, Nedumaran AM, …, Gulyás B, et al. (2017). Theranostic Probes for Targeting TumorMicroenvironment: An Overview. International Journal of Molecular Science. 2017 May 11;18(5):E1036.

Sridhar S, Mishra S, …, Gulyás B (2017). An Overview of Multimodal Neuroimaging Using Nanoprobes. International Journal of Molecular Science. 18(2):311. 

Kumar A, Narayanan K, …, Gulyás B. (2017). Current Perspective of Stem Cell Therapy in Neurodegenerativeand Metabolic Diseases. Molecular Neurobiology. 54(9):7276-96.

Yang CT, Padmanabhan P, & Gulyás B. (2016). Gadolinium (iii) based nanoparticles for T 1-weighted magnetic resonance imaging probes. RSC Advances. 65: 60945-66.


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