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Chew Sing Yian

Chew Sing Yian-01 (Custom).jpg

Associate Professor Chew Sing Yian 
PhD
Associate Professor, School of Chemical & Biomedical Engineering,
Associate Professor, Lee Kong Chian School of Medicine,
Nanyang Technological University
Email: sychew@ntu.edu.sg 
Website: www.ntu.edu.sg/home/sychew



Team

  • Dr Coline PINESE, PhD, Research Fellow
  • Dr Ulla MILBRETA, PhD, Research Fellow
  • Dr CHOOI Wai Hon, PhD, Research Fellow
  • NGUYEN Lan Huong, Project Officer​
  • PENG Yanfen, Project Officer​
  • William ONG, Ph.D. student
  • LIN Junquan, PhD student
  • ZHANG Na, PhD student
  • CHIN Jiah Shin, PhD student


Introduction

Associate Professor Chew Sing Yian is an Associate Professor at the Lee Kong Chian School of Medicine (LKCMedicine) and the School of Chemical & Biomedical Engineering (SCBE), Nanyang Technological University (NTU), Singapore. A/Prof Chew obtained her PhD at Johns Hopkins University in 2006, under the sponsorship of the NTU Overseas Scholarship. Thereafter, she joined SCBE as Assistant Professor later in the same year. In 2012, A/Prof Chew received her tenure and was promoted to Associate Professor in SCBE. In March 2014, A/Prof Chew received joint appointment with LKCMedicine. Starting July 2014, she serves as Associate Chair of Research in SCBE.

A/Prof Chew is known for her contributions to the field of regenerative medicine and stem cell engineering. Her research interests lie in understanding the combined effects of nanotopography and biochemical signalling in directing cell fate. Specifically, her lab engineers nanofiber platforms for long-term delivery of biochemicals. Currently, A/Prof Chew’s work focuses on scaffold-mediated delivery of small non-coding RNAs for long-term gene silencing applications. These biofunctional platforms are used for understanding and directing neural tissue regeneration post-traumatic injuries, stem cell fate and host-implant integration.

Since joining NTU, A/Prof Chew has continued to embark on scientific learning and exchanges by serving as visiting scholar/professor to INSERM (U698 and U791); University of Paris 13; University of Nantes; Jinan University in Guangzhou, China; and Wyss Institute at Harvard. She also serves as the editorial board member in Drug Delivery and Translational Research, a new official journal of the highly regarded Controlled Release Society. Her professional experience also includes evaluating research grants for local and international funding bodies including the Research Grant Council of Hong Kong.


Research Focus

The Chew Laboratory​ engineers bio-functional micro- and nano-structured scaffolds to understand and direct cellular behavior. They use combinatorial approaches involving substrate topography/compliance and biochemical cues to mediate tissue regeneration and host-implant integration.

Their works range from fundamental science to scaffold, drug/gene delivery technology development; and translational research. Currently, they focus on scaffold-mediated gene-silencing approaches to understand and direct neural tissue regeneration, stem cell differentiation and host-implant integration.

Their main objective is to provide improved platforms for better understanding and control over cell fate for regenerative medicine.

The Cell & Tissue Engineering Lab - Engineering bioinspired drug/gene-delivery scaffolds for directing cell fate.

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Key Publications

Milbreta U, Huong NL, … Chew SY. (2016). Three-dimensional nanofiber hybrid scaffold directs and enhances axonal regeneration after spinal cord injury. ACS Biomaterials Science & Engineering, 2(8):1319-1329.

Diao HJ, Wang K, … Chew SY. (2016). Highly fluorescent and photostable polymeric nanofibers as scaffolds for cell interfacing and long-term tracking. Advanced Healthcare Materials, 5(5):529-533.


Chew SY (2015). MicroRNAs in tissue engineering and regenerative medicine. Advanced Drug Delivery Reviews, 88:1-2.

Nguyen LH, Diao HJ, & Chew SY. (2015). MicroRNAs and their potential therapeutic applications in neural tissue engineering. Advanced Drug Delivery Reviews, 88:53-66.

Diao HJ, Low WC, …,Chew SY. (2015)Nanofiber-mediated microRNA delivery to enhance differentiation and maturation of oligodendroglial precursor cells. Journal of Controlled Release.

Yau WW, Long H, …, Chew SY. (2015). The effects of nanofiber diameter and orientation on siRNA uptake and gene silencing. Biomaterials, 37C:94-106.

Jiang X, Mi R, …, Chew SY. (2014). Nanofibrous nerve conduit-enhanced peripheral nerve regeneration. Journal of Tissue Engineering and Regenerative Medicine, 8(5):377-385.

Low WC, Rujitanaroj P, …Chew SY (2013). Nanofibrous scaffold-mediated REST knockdown to enhance neuronal differentiation of stem cells. Biomaterials, 34(14): 3581-3590.


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