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Christine Cheung

Christine Cheung (Custom).jpg

 



Assistant Professor Christine Cheung
PhD
Nanyang Assistant Professor and Provost's Chair in Medicine
Principal Investigator, Molecular and Vascular Medicine


Team

  • Dr Wu Kanxing, Research Fellow
  • Dr Shuba Krishnan, Research Fellow
  • Dr Ng Chun-Yi, Research Fellow
  • Dr Noreen binte Ishak, Research Fellow
  • Mr Tian Xianfeng, Senior Research Associate
  • Ms Florence Chioh, Research Assistant
  • Ms Natalie Yeo Jia Ying, PhD Student
  • Ms Tay Kai Yi, FYP Student


Introduction

Assistant Professor Christine Cheung is a Nanyang Assistant Professor in Lee Kong Chian School of Medicine, Nanyang Technological University, and an awardee of the 2016 Nanyang Assistant Professorship. She received a PhD in Cardiovascular and Stem Cell Medicine from the University of Cambridge, and a BEng (First Class) from Imperial College London. For her pioneering approach to create organ-specific blood vessels, she was recognised with the Young Investigator Prize from the British Society for Cardiovascular Research. Notably, she is the World Economic Forum Young Scientist, Honoree of the Ten Outstanding Young Persons of Singapore by Junior Chamber International, and Life Science Fellow of L'Oréal-UNESCO For Women in Science National Fellowship. To advance her work, she is an awardee of the prestigious Human Frontier Science Program (HFSP) research grant. She currently serves on the executive committee of Stem Cell Society Singapore.


Research Focus

The crux of many diseases lies in the blood vessels. We are finding means to restore blood vessel health before adverse outcomes of diseases occur, with the goal of working towards preventive medicine. Main thrusts of our research include:

Personalised Vascular Models
Our lab invents methods to convert human stem cells to blood vessel cells, resembling those found in the heart and brain arteries. We also develop blood outgrowth endothelial cells directly from patients with vascular complications. These cellular models recapitulate the phenotypic and molecular changes associated with vascular pathology, opening the door to drug screening and regenerative medicine.
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Genetic Basis of Vascular Ageing
Blood vessels in various organs behave differently despite similar genetic and systemic conditions. This may explain why diseases like cerebral amyloid angiopathy and CADASIL uniquely affect the vasculatures of the brain. We aim to understand how certain genetic disorders preferentially inflict vascular beds of specific organs. By employing genome editing tools and cell-based phenotypic assays, we hope to explore pathogenic mechanisms which pave the way for developing vascular-targeted therapies. 

Vascular Disease Biomarkers
There remain significant knowledge gaps in the functional interpretation of clinical biomarkers in whether they are causal or a consequence in the disease process. Leveraging on our collaborations with clinicians, we elucidate biomarkers relating to key vascular processes such as blood vessel instability and inflammation. Deep-dive elucidation of such molecular signatures will enable us to unravel implicated pathways, and achieve better diagnostics for early intervention.


Selected Publications

Cheung C, Bernardo AS, Trotter MW, et al. (2012). Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility. Nature Biotechnology, 30(2), 165-73

Cheung C, Bernardo AS, Pedersen RA, et al. (2014). Directed differentiation of embryonic origin-specific vascular smooth muscle subtypes from human pluripotent stem cells. Nature Protocols, 9, 929-938.

Trigueros-Motos L, Gonzalez-Granado JM, Cheung C, et al. (2013). Embryological-origin-dependent differences in homeobox expression in adult aorta: role in regional phenotypic variability and regulation of NF-κB activity. Arteriosclerosis, Thrombosis, and Vascular Biology, 33(6), 1248-56.


Narmada BC, Goh YT, … Cheung C. (2016)Human stem cell-derived endothelial-hepatic platform for efficacy testing of vascular-protective metabolites from nutraceuticals. Stem Cells Translational Medicine, 6(3), 851-863.

r J, Low L, Cheung C, et al. (2016). Embryological Origin of Human Smooth Muscle Cells Influences Their Ability to Support Endothelial Network Formation. Stem Cells Translational Medicine, 5(7), 46-59.

Ng GJL, Quek AML, Cheung C, et al. (2017). Stroke biomarkers in clinical practice: A critical appraisal. Neurochemistry International, 107, 11-22.

Kiskin FN, Chang C,… Cheung C, et al. (2018). Contribution of BMPR2 mutations and extrinsic factors in cellular phenotypes of pulmonary arterial hypertension. American Journal of Respiratory and Critical Care Medicine, 198(2), 271-275. 

SSY Chan, YS Tan, K Wu, C Cheung, DK Loke. (2018). Ultra-high signal detection of human embryonic stem cells driven by two-dimensional materialsACS Applied Bio Materials, 1(2), 210–215.

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