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Lim Kah Leong

Prof Lim Kah Leong.jpg



Professor Lim Kah Leong
PhD
Vice-Dean (Research)
Lee Kong Chian School of Medicine 
Introduction

Professor Lim Kah Leong is Vice-Dean (Research), who leads the strategic development and implementation of the School’s research programme, working closely with the Dean and the senior leadership of LKCMedicine, NTU and Imperial College London to advance institutional initiatives for research excellence.
 
Professor Lim is a renowned scientist in the areas of neuroscience and mental health, particularly in the field of Parkinson’s Disease. With a long-term goal to elucidate the molecular events underlying Parkinson’s Disease and to effectively treat the disease, his research centres on mechanisms underlying neurodegeneration which will reveal targets for neuroprotection. He is also developing new research technologies in the area of stem cells and neurorestoration as well as in diagnostics and neurotechnology, where he collaborates extensively with chemists, material scientists and engineers. 
 
Prior to joining LKCMedicine, Professor Lim was a recipient of numerous awards including the prestigious President’s Science Award (Team) and Singapore Neuroscience Association Distinguished Neuroscientist Award. He was previously Head of the Department of Physiology at the National University of Singapore and Deputy Research Director at the National Neuroscience Institute.


Selected Publications 

Teh, B., Bansal, A., Chai, C., Toh, T.B., Jappy Tucker, R.A., Gammad, G.G.L., Yeo, Y., Lei, Z., Zheng, X., Feng, Y., Ho, J., Bolem, N., Wu, B.C., Gnanasammandhan, M.K., Hooi, L., Dawe, G.S.,  Libedinsky, C., Ong, W.Y., Halliwell, B., Chow, E.K.H., Lim, K.L.*, Zhang, Y.*, Kennedy, B*. (*co-corresponding) Flexi-PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy. Advanced Materials (Accepted)  

Rajan S, Jang Y, Kim CH, Kim W, Toh HT, Jeon J, Song B, Serra A, Lescar J, Yoo JY, Beldar S, Ye H, Kang C, Liu XW, Feitosa M, Kim Y, Hwang D, Goh G, Lim K.L., Park HM, Lee CH, Oh SF, Petsko GA, Yoon HS, Kim KS (2020). PGE1 and PGA1 bind to Nurr1 and activate itstranscriptional function. Nature Chemical Biology, May 25, 2020 (Online ahead of print). https://doi.org/10.1038/s41589-020-0553-6​


Sun, A.X., Yuan, Q., Fukuda, M., Yu, W., Yan, H.D., Lim, G.G.Y., Nai, H.H., D'Agostino G.A., Tran, H., Itahana, Y., Wang, D., Lokman, H., Itahana, K., Lim, S.W.L., Tang, J., Cook, S.A., Rackham, Lim, C.T., Tan, E.K., Ng, H.H., Lim, K.L., Jiang, Y., Je, S. (2019). 
Potassium channel dysfunction in human neuronal models of Angelman syndromeScience, 366 (6472): 1486:1492. doi: 10.1126/science.aav5386​

Lim, G.G. and Lim, K.L. (2017). 
Parkin-independent Mitophagy-FKBP8 takes the stageEMBO Reports18(6):864-865. doi: 10.15252/embr.201744313​

Ng, C.H., Basil, A.H., Hang, L.T., Tan, R., O’Neill S., Zhang, X.D., Yu, F., Lim, K.L. (2017). 
Genetic or pharmacological activation of the Drosophila PGC-1α ortholog spargel rescues the disease phenotypes of genetic models of Parkinson’s diseaseNeurobiology of Aging, 55:33-37. doi
  • 10.1016/j.neurobiolaging.2017.03.017


  • Nucifora, F.C., Nucifora, L.G., Ng, C.H., Arbez, N., Guo, Y., Roby, E., Shani, V., Engelender, S., Wei, D., Wang, X.F., Li, T., Moore DJ, Pletnikova, O., Troncoso, J., Sawa, A., Dawson, T.M., Smith, W.,
    Lim, K.L., Ross, C.A. (2016). Ubiqutinationvia K27 and K29 chains signals aggregation and neuronal protection of LRRK2 byWSB1​. Nature Communications, 7:11792. https://doi.org/10.1038/ncomms11792​

    Li, L., Zhang C.W., P., Chen G.Y.J., Zhu, B., Y.W., Chai. C., Xu, Q., Tan, E.K., Kung, S.K.P., Lim, K.L.*, Yao, S.Q. 
    (*co-corresponding). (2014). A sensitive two-photon probe to selectively detect monoamine oxidase B activity in Parkinson’s disease modelsNature Communications5:3276. doi10.1038/ncomms4276

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