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Luo Dahai

Luo Dahai-01 (Custom).jpg
Associate Professor Luo Dahai 
PhD
Associate Professor of Infection and Immunity and Provost's Chair in Medicine 
Principal Investigator, Molecular Mechanisms of Viral ​Infection & Host Defense Laboratory


Team

  • ​Law Yee Song, PhD, Research Fellow
  • Melissa Wirawan, PhD, Research Fellow
  • Kuo Zhang, PhD, Research Fellow
  • Nguyen Mai Trinh, Research Assistant
  • Tay Jiliang, Research Assistant
  • Alvin Chew Bing Liang, PhD student
  • Quek Jun Ping, PhD student
  • Huynh Phuong Thao, PhD student
  • Tan Yaw Bia, PhD student
  • Van Den Elsen Kain Elisabeth Franciscus, PhD student


Introduction
 

Associate Professor Luo Dahai received his BSc in 2006 and his PhD in 2010 from the School of Biological Sciences, Nanyang Technological University, Singapore. He studied at Yale University as a postdoctoral research associate (2010-2013) before joining Lee Kong Chian School of Medicine (LKCMedicine) in Sept 2013.


 
Research Focus

​​​​

The primary research interest of his lab is to understand the molecular events involved in the battle between host and pathogens, in particular between RNA viruses and humankind. The main objective of the laboratory is to study the molecular biology of RNA and RNA-protein complexes, branching into two interrelated directions: (1) A complete and dynamic view of the viral RNA biogenesis; (2) Systematic study of the intracellular pathogenic RNA sensing and response. The laboratory applies biochemical, biophysical, structural, and in vivo approaches to study the biogenesis of the pathogenic RNA species and the host’s counteracting defense mechanisms.

Assoc Prof Luo and his team enjoy collaborations with scientists from different fields, chemists, virologists, immunologists, cell biologists and physicians. Together, they are devoted to provide:
(1) Comprehensive understanding the conflict between host and pathogens;
(2) Unique and deep Insights for Drug and Vaccine Development.
The laboratory is also interested in
(3) Molecular engineering at the interface between RNA and protein;
(4) Novel methods and tools for basic research, diagnostics and therapeutics.​

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Selected Publications

Yong, H.Y., Zheng, J., Ho, V.C.Y., Nguyen, M.T., Fink, K., Griffin, P.R., Luo, D. (2019). Structure-guided design of immunomodulatory RNAs specifically targeting the cytoplasmic viral RNA sensor RIG-I. FEBS Letters. 593(21):3003-3014. doi: 10.1002/1873-3468.13564

Law, Y.S., Utt, A., Tan, Y.B., Zheng, J., Wang, S., Chen, M.W., Griffin, P.R., Merits, A., Luo, D. (2019). Structural insights into RNA recognition by the Chikungunya virus nsP2 helicase. Proceedings of the National Academy of Sciences of the United States of America. 116(19):9558-9567. doi: 10.1073/pnas.1900656116

Phoo, W.W., Zhang, Z., Wirawan, M., Chew, E.J.C., Chew, A.B.L., Kouretova, J., Steinmetzer T, Luo, D. (2018). Structures of Zika virus NS2B-NS3 protease in complex with peptidomimetic inhibitors. Antiviral Research. 160:17-24. doi: 10.1016/j.antiviral.2018.10.006

Yong, H.Y., Luo, D. (2018). RIG-I-Like Receptors as Novel Targets for Pan-Antivirals and Vaccine Adjuvants Against Emerging and Re-Emerging Viral Infections. Frontiers in Immunology. 9:1379. doi: 10.3389/fimmu.2018.01379.

Chen, M.W., Tan, Y.B., Zheng, J., Zhao, Y., Lim, B.T., Cornvik, T., Lescar, J., Ng, L., Luo, D. (2017). Chikungunya virus nsP4 RNA-dependent RNA polymerase core domain displays conditional, detergent-sensitive primer extension and terminal adenylyltransferase activities. Antiviral Research. 143:38-47. doi: 10.1016/j.antiviral.2017.04.001.

Phoo, W.W., Li, Y., Zhang, Z., Lee, M.Y., Loh, Y.R., Tan, Y.B., Ng, E.Y., Lescar, J., Kang, C., Luo, D. (2016). Structure of the NS2B-NS3 Protease from Zika Virus Caught after Self-Cleavage. Nature Communications. 7:13410. doi: 10.1038/ncomms13410

Zhao, Y., Soh, T.S., Lim, S.P., Chung, K.Y., Swaminathan, K., Vasudevan, S.G., Shi, P.Y., Lescar, J., Luo, D. (2015) Molecular basis for specific viral RNA recognition and 2'-O ribose methylation by the dengue virus NS5 protein. Proceedings of the National Academy of Sciences of the United States of America. 112(48):14834-9. doi: 10.1073/pnas.1514978112

Zhao, Y., Soh, S., Zheng, J., Phoo, W.W., Swaminathan, K., Cornvik, T.C., Lim, S.P., Shi, P.-Y., Lescar, J., Vasudevan, S.G., Luo, D. (2015). A Crystal Structure of the Dengue Virus Ns5 Protein Reveals a Novel Inter-Domain Interface Essential for Protein Flexibility and Virus Replication. PLoS Pathogens. 11(3):e1004682. https://doi.org/10.1371/journal.ppat.1004682

Zheng, J., Yong, H.Y., Panutdaporn, N., Liu, C., Tang, K., Luo, D. (2015). High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5. Nucleic Acids Research. 43(2):1216-30. doi: 10.1093/nar/gku1329


* Complete list of publications: Google Scholar​

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