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Melvin Leow

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Associate Professor Melvin Leow
Associate Professor


Associate Professor Melvin Leow is Associate Professor in the Lee Kong Chian School of Medicine at Nanyang Technological University. He is also a Senior Consultant Endocrinologist affiliated to the Department of Endocrinology at Tan Tock Seng Hospital. He is a Clinician Scientist and holds a joint appointment as Clinical Investigator at the Singapore Institute for Clinical Sciences at A*STAR. He is concurrently the Deputy Director of the Clinical Nutrition Research Centre located at the Centre for Translational Medicine in the NUHS campus. His other appointments include clinical associate professor at Yong Loo Lin School of Medicine and adjunct associate professor at Duke-NUS Medical School. A/Prof. Leow is an elected Fellow of the American College of Endocrinology, the American College of Physicians, the Royal College of Physicians of Edinburgh, the Royal College of Pathologists and the Academy of Medicine (Singapore).

  • National Healthcare Group (NHG) Doctor Award (2004)
  • Researcher-Investigator-Scientist-Enabler (RISE) Award (2008)
  • Investigator-Clinician Award (NHG) (2008)
  • Clinician Scientist Career Scheme (Senior) Award (2014)
  • Clinician Scientist Award (Investigator) (NMRC) (2015 & 2018)
  • NHG-NTU/LKC Med Clinician Scientist Fellowship Award (2015)

  • ​System and method for deriving parameters for homeostatic feedback control of the hypothalamic-pituitary-thyroid axis of an individual (co-inventor).
  • Copyright application for Thyroid set point optimization and targeting software for Android and iPhone apps (co-inventor).

Research Focus

A/Prof Leow's research group focuses on energy metabolism and metabolic physiology including feedback loops regulating the intricate network of the gastrointestinal tract, pancreas, adipose tissue, thyroid, liver and skeletal muscles. His field of interests includes adipocyte biology, metabolic syndrome/diabetes, thyroidology, endocrine manifestations of systemic disorders and mathematical modeling of endocrine physiology in which he has published works in international refereed journals. His present focus is on brown adipose tissue, thermogenesis and the browning of white adipocytes with nutraceuticals, pharmaceuticals and endogenous peptides and hormones.

Selected Publications

Parvaresh E, Leow MK, Khoo EY, et al. (2015). Ethnic differences in the role of adipocytokines linking abdominal adiposity and insulin sensitivity among Asians. The Journal of Clinical Endocrinology & Metabolism.

Than A, He HL, …, Leow MK, et al. (2015). Apelin enhances brown adipogenesis and browning of white adipocytes. The Journal of Biological Chemistry.

Than A, Cheng YQ, …, Leow MK, Lim SC, et al. (2012). Apelin inhibits adipogenesis and lipolysis. Molecular and Cellular Endocrinology.

* Complete publications list: PubMed

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