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Navin Verma

Navin Verma-01 (Custom).jpg
 

Assistant Professor Navin Kumar Verma
PhD
Assistant Professor of Immunology and Cell Biology
Principal Investigator, Lymphocyte Signalling Research Laboratory



  
Team
 
  • ​Dr Seow Theng Ong, PhD, Senior Research Fellow
  • Dr Mobashar Hussain Urf Turabe Fazil, PhD, Research Fellow
  • Dr Madhavi Latha Somaraju Chalasani, PhD, Research Fellow
  • Ms Praseetha Rajesh Chandramohanadas, Research Assistant
  • Mr Atish Kizhakeyil, PhD student


Introduction


Assistant Professor Navin Kumar Verma is an Assistant Professor of Immunology and Cell Biology at the Lee Kong Chian School of Medicine, Nanyang Technological University. He obtained a PhD in Clinical Medicine from Trinity College Dublin (TCD), Ireland’s most prestigious University. He then undertook postdoctoral research training at the Institute of Molecular Medicine, TCD, where he studied the integrin LFA-1-mediated signalling pathways involved in T-cell migration and effector functions. He was trained in various aspects of Immunology, Cell Biology, Hematolymphoid Malignancies and Nanomedicine.

 

Asst Prof Verma has made significant contribution in the area of lymphocyte signalling. He has published more than 45 peer-reviewed papers which are widely cited (h-Index 17) in the fields of immunology, cell biology, cell signalling, pharmacology, toxicology and nanomedicine. In a recent ground-breaking discovery, his research team demonstrated a novel gene silencing technique applied to primary human T-lymphocytes using molecularly-targeted GapmeR. He is the co-author of eight patents.

 

Asst Prof Verma has received several awards and prizes for his scientific achievements. These include the Glory of India Award, SERS Fellow, best presentation awards at scientific conferences and the first prize for outstanding business plan of his research in the Trinity Heat of Idea to Product (I2P) coordinated by the University of Texas at Austin I2P® Program. He has served as a reviewer for national and international research grants and scientific journals.


Research Focus


The main research interest of the lab is centered on developing new ways to treat immune-mediated inflammatory disorders (e.g. rheumatoid arthritis, psoriasis), skin diseases (e.g. melasma, atopic dermatitis), superficial infections (e.g. skin/wound infections) and cancer (hematolymphoid malignancies). His research team employs cutting-edge tools and advanced technologies to understand disease mechanisms at subcellular and molecular levels using various in vitro and in vivo model systems.

Research in Asst Prof Verma’s lab is focused on the following major multidisciplinary projects:
 
  1. Elucidation of molecular processes mediated via adhesion receptors in lymphocytes; in particular, biological roles and functional significance of the integrin LFA-1 and associated signaling and adaptor proteins in T-cell migration.
  2. Identification of signaling protein interactome involved in the active locomotion of T-lymphocytes.
  3. Characterization of inflammatory skin disorders for biomarker discovery.
  4. Development of novel gene silencing-based therapeutic strategy that could be combined with nanotechnology enabled controlled-release drug delivery systems for targeting skin diseases, hematolymphoid malignancies and other cancer, in addition to immunotherapeutic applications.
  5. Exploitation of the anti-inflammatory and anti-infective properties of multi-functional bioactive peptides/polymers for treating superficial infections and wound applications.​

High Content T cell migratory phenotypes.jpg T stimulated cytoskeletal remodelling.jpg

High Content Analysis (HCA) of T-cell migratory phenotypes. Mechanism by which PKCε-Rab5a-Rac1 axis regulates LFA-1/ICAM-1-stimulated cytoskeletal remodelling in motile T-cells.
Activation and regulation of microtubule dynamics.jpg
treated T cell.jpg
A model for LFA-1-induced STAT3 activation and regulation of microtubule dynamics. Super-resolution image of GapmeR (green) treated T-cell showing assoc​iation with macropinosomes (red).
 ​

Selected Publications

Verma NK, & Kelleher D. (2017). Not just an adhesionmolecule: LFA-1 contact tunes the T lymphocyte program. Journal of Immunology. 199(4):1213-21.


Chu TTT, Sinha A, ... Verma NK, et al. (2017). Quantitative mass spectrometry ofhuman reticulocytes reveal proteome-wide modifications during maturation. British Journal of Haematology. 180(1):118-33.


Dhand C, Venkatesh M, ... Verma NK, et al. (2017). Bio-inspiredcrosslinking and matrix-drug interactions for advanced wound dressings withlong-term antimicrobial activity. Biomaterials. 138:153-68.


Fazil MHUT, Ong ST, ... Verma NK. (2016). GapmeR cellularinternalization by macropinocytosis induces sequence-specific gene silencing inhuman primary T-cells. Scientific Reports. 6:37721.


Verma NK, Fazil MHUT, Ong ST, et al. (2016). LFA-1/ICAM-1 ligation in human T-cells promotes Th1 polarization through aGSK3β signaling-dependent Notch pathway. Journal of Immunology. 197(1):108-18.


Liow SS, Dou Q, ... Verma NK, et al. (2016). Long-term real-time in vivodrug release monitoring with AIE thermogelling polymer. Small. 13(7).


Fox SJ, Fazil MHUT, ... Verma NK, et al. (2016). Insight into the membrane selectivity of linear andbranched polyethylenimines and their potential as biocides for advanced wounddressings. Acta Biomaterialia. 37:155-64.


Ong ST, Freeley M, ... Verma NK, et al. (2014). Phosphorylation of Rab5a by protein kinase Cε is crucialfor T-cell migration. Journal of Biological Chemistry. 289:19420-34.


Lysaght J, Verma NK, Maginn EN, et al. (2013). The microtubule targeting agent PBOX-15 inhibitsintegrin-mediated cell adhesion and induces apoptosis in acute lymphoblasticleukaemia cells. International Journal of Oncology. 42:239-46.


Verma NK, Dempsey E, Long A, et al. (2012). Leukocytefunction-associated antigen-1/intercellular adhesion molecule-1 interactioninduces a novel genetic signature resulting in T-cells refractory totransforming growth factor-β signalling​Journal of Biological Chemistry. 287:27204-16.


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