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Per-Olof Berggren

​​Per-Olof Berggren-01 (Custom).jpg


Professor Per-Olof Berggren
PhD
Visiting Professor
Principal Investigator, Islets Biology Laboratory​




Team

  • Dr Zheng Xiaofeng, PhD, Research Fellow
  • Riasat Hasan, Research Associate
  • Minni Chua, Research Assistant

Introduction

Professor Per-Olof Berggren is Professor and Head of Cell Biology and Experimental Endocrinology, Department of Molecular Medicine and Surgery, Director The Rolf Luft Research Center for Diabetes and Endocrinology at Karolinska Institutet in Stockholm, Sweden. In 2013, Prof Berggren joined NTU as a Visiting Professor at LKCMedicine, Metabolic Disease Research Program. Prof Berggren acquired his PhD in Medical Cell Biology at the University of Uppsala and has published 383 articles in peer-reviewed journals.

Throughout his scientific career, Prof Berggren has done pioneering work regarding the fundamental mechanisms regulating the stimulus-response coupling in the endocrine pancreas with several seminal contributions within the fields of insulin secreting pancreatic beta-cell Ca2+ handling, phosphorylated inositol compounds and insulin receptor operated signalling.


Research Focus

The Berggren laboratory is interested in understanding molecular aspects of pancreatic islet cell biology, cell physiology, cell pathology, mechanisms involved in insulin secretion and glucose homeostasis,  Ca2+ signaling and cellular cross-talk.


Key Publications

Rodriguez-Diaz R, Molano RD, …, Berggren PO. (2018). Paracrine interactions within the pancreatic islet determine the glycemic set point. Cell Metabolism, 27: 549-558.

Diez JA, Arrojo E Drigo R, …, Berggren PO. (2017). Pancreatic islet blood flow dynamics in primates. Cell Reports, 20: 1490-1501.

Abdulreda MH, Rodriguez-Diaz R, Caicedo A, Berggren PO. (2016). Liraglutide compromises pancreatic beta cell function in a humanized mouse model. Cell Metabolism, 23: 541-546. 

Gerdes JM, Christou-Savina S, …, Berggren PO. (2014). Ciliary dysfunction impairs pancreatic insulin secretion and promotes development of type 2 diabetes in rodents. Nature Communications, DOI: 1038/ncomms6308.

Ilegems E, Dicker A,…, Berggren PO. (2013). Reporter islets in the eye reveal the plasticity of the endocrine pancreas. Proceedings of the National Academy of Sciences of the United States of America, 110: 20581-20586.

Abdulreda MH, Faleo G, .., Berggren PO. (2011). High-resolution, non-invasive longitudinal live imaging of immune responses. Proceedings of the National Academy of Sciences of the United States of America, 108: 12863-12868.

Cabrera O, Jacques-Silva MC, …, Berggren PO. (2008). Glutamate is a positive autocrine signal for glucagon release. Cell Metabolism, 7: 545-554.

Speier S1, Nyqvist D, .., Berggren PO. (2008). Non-invasive in vivo imaging of pancreatic islet cell biology. Nature Medicine, 14: 574-578.

Illies C, Gromada J, .., Berggren PO. (2007). Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic b-cells. Science, 318: 1299-1302.


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