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Wang Yulan

Prof Wang Yulan (Custom).jpg



Professor Wang Yulan 
Professor of Metabolomics
  • ​Dr Low Yanwen Dorrain

Introduction​​

Professor Wang Yulan is a professor of Metabolomics at LKCMedicine and Director of Singapore Phenome Centre (SPC). She also has an honorary appointment with the School of Public Health at Imperial College London. 

Prof Wang obtained her PhD in Physical Chemistry in 1997 from University of East Anglia, UK. After her PhD, Prof Wang joined the Institute of Food Research and John Innes Center, UK, where she spent 1998 to 2001 on postdoctoral research, applying her Nuclear Magnetic Resonance (NMR) skills in food sciences. From 2001 to 2007, Prof Wang worked at Imperial College London, in the field of metabonomics as research fellow. In 2007, she was recruited as part of China’s “1000 talents program” by the Chinese Academy of Science and became a professor at the Wuhan Institute of Physics and Mathematics. She used NMR and Liquid Chromatography – Mass Spectrometry (LC-MS) spectroscopic techniques with computational modelling techniques to investigate the metabolic effects of infectious diseases and nutritional interventions.


Research Focus

Prof Wang believes that advances in research rely on the breakthrough of new technology. She will focus her research on developing metabonomics techniques, including NMR and MS-based techniques. Quantitatively detecting as many metabolites as possible with the highest sensitivity and throughput is the ultimate goal of metabolic profiling. Since cell-to-cell variability can contribute to antibiotic resistance and cancer re-occurrence, measurement of single cells metabolomics at high throughput becomes necessary to elucidate new mechanisms in health and diseases. Development of high throughput single cell metabolomics is one her current focus. In addition, Prof Wang is interested in metabolic impact of infectious diseases, such as HBV infection, co-infections and gut microbial-host interactions. Furthermore, metabonomics is a very useful tool for generating credible hypotheses that can be applied to many other areas, such as gastroenterological diseases, cancer, metabolic diseases, neurodegenerative diseases, drug resistance and environmental sciences as well as dietary studies. Prof Wang is interested in collaboration with scientists in these fields. 

Finally, the important role of preventive medicine in health management relies on detecting the onset of disease. Metabolic alteration during onset of disease could be detected using metabolomics tools; therefore, applications of metabolomics on population phenotyping and detecting early onset of a range of chronical diseases, such as diabetes and coronary heart disease is one of another area of interest. 

Selected Publications

Y.L. Hu, X.Y. Zhu, R.F. Zhao, J. Wang, Y.P. Song, G.J. Nie, H.R. Tang, Y.L. Wang, Doxorubicin and paclitaxel carried by methoxypoly(ethylene glycol)-poly (lactide-co-glycolide) is superior than traditionaldrug-delivery methods, Nanomedicine, 2018.​

Q.F. Wan, Y.L. Wang, H.R. Tang, Quantitative13C traces of glucose fate in hepatitis B viral-infected hepatocytes, Analytical Chemistry, 89, 3293-3299, 2017. 

J. Wang, L.H. Zhou, H.H. Lei, F.H. Hao, X. Liu, Y.L. Wang, H.R. Tang, Simultaneous quantification of amino metabolites in multiple metabolic pathways using ultra-high-performance liquid chromatography with tandem-mass spectrometry, Scientific Reports, 7:1423, 2017. 

X.Y. Zhu, L. Chen, J.F. Wu, H.R. Tang, Y.L. Wang, Salmonella typhimurium Infection Reduces Schistosoma japonicum Worm Burden in Mice, 2017, Scientific Reports, 7:1349, 2017.

J.T. Bjerrum, C. Steenholdt, M. Ainsworth, O.H. Nielsen, M.A. Reed, K. Atkins, U.L. Günther, F.H. Hao, Y.L. Wang. Metabonomics uncovers a reversible proatherogenic lipidprofile during infliximab therapy of inflammatory bowel disease. BMC Med., 15(1):184, 2017. 

H.D. Li, W. Stokes, E. Chater, R. Roy, E. de Bruin, Y.L. Hu, Z.G. Liu, E. F. Smit, G. Heynen, J. Downward, M.J. Seckl, Y.L. Wang, H.R. Tang, O.E. Pardo, Decreased glutathione biosynthesis contributes toEGFR T790M-driven erlotinib resistance in non-small cell lung cancer, Cell Discovery, 2, 31, 2016.


Z.G. Liu, L.M. Wang, L.M. Zhang, X.C. Wu, G.J. Nie, C.Y. Chen, H.R. Tang, Y.L. Wang, Metabolic characteristics of 16HBE andA549 cells exposed to different surface modified gold nanorods,
Advanced Healthcare Materials, 5:28, 2363-2375, 2016.

J.F. Wu, B. Fu, H.H. Lei, H.R. Tang*, Y.L. Wang, Gender differences of peripheral plasma and liver metabolic profiling inAPP/PS1 transgenic AD mice,
Neuroscience, 332, 160-169, 2016. 

Y. Tian, T.P. Xu, J. Huang, L.M. Zhang, S. Xu, B.Xiong, Y.L. Wang, H.R. Tang, Tissue metabonomic phenotyping for diagnosisand prognosis of human colorectal cancer,
Scientific Reports, 6:20790, 2016.

H. Lin, Y.P. An, F.H. Hao, Y.L. Wang, H.R. Tang, Correlations of fecal metabonomic and microbiomic changes inducedby high-fat diet in the pre-obesity state​,
Scientific Reports, 6:21618, doi: 10.1038/srep21618, 2016.


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