​Assoc Prof Leow Khee Shing, Melvin

melvin leow.jpg
A/Prof. Melvin Khee Shing Leow is Associate Professor in the Lee Kong Chian School of Medicine at Nanyang Technological University. He is also a Senior Consultant Endocrinologist affiliated to the Department of Endocrinology at Tan Tock Seng Hospital. He is a Clinician Scientist and holds a joint appointment as Clinical Investigator at the Singapore Institute for Clinical Sciences at A*STAR. He is concurrently the Deputy Director of the Clinical Nutrition Research Centre located at the Centre for Translational Medicine in the NUHS campus. His other appointments include clinical associate professor at Yong Loo Lin School of Medicine and adjunct associate professor at Duke-NUS Medical School. A/Prof. Leow is an elected Fellow of the American College of Endocrinology, the American College of Physicians, the Royal College of Physicians of Edinburgh and the Academy of Medicine (Singapore).
Research Focus

His research group focuses on energy metabolism and metabolic physiology including feedback loops regulating the intricate network of the gastrointestinal tract, pancreas, adipose tissue, thyroid, liver and skeletal muscles. His field of interests includes adipocyte biology, metabolic syndrome/diabetes, thyroidology, endocrine manifestations of systemic disorders and mathematical modeling of endocrine physiology in which he has published works in international refereed journals. His present focus is on brown adipose tissue, thermogenesis and the browning of white adipocytes with nutraceuticals, pharmaceuticals and endogenous peptides and hormones.

National Healthcare Group (NHG) Doctor Award (2004), Researcher-Investigator-Scientist-Enabler (RISE) Award (2008), Investigator-Clinician Award (NHG) (2008), Clinician Scientist Career Scheme (Senior) Award (2014), Clinician Scientist Award (Investigator) (NMRC) (2015), NHG-NTU/LKC Med Clinician Scientist Fellowship Award (2015)

1. System and method for deriving parameters for homeostatic feedback control of the hypothalamic-pituitary-thyroid axis of an individual (co-inventor).

2. Copyright application for Thyroid set point optimization and targeting software for Android and iPhone apps (co-inventor).

Selected Publications
1. Ohba K, Leow MK, Singh BK, Sinha RA, Lesmana R, Liao XH, Ghosh S, Refetoff S, Sng JC, Yen PM. Desensitization and incomplete recovery of hepatic target genes after chronic thyroid hormone treatment and withdrawal in male adult mice. Endocrinology 2016; 157: 1660-72.
2. Parvaresh E, Leow MK, Khoo EY, Toh SA, Tai ES, Chong YS, Lee YS, Gluckman PD, Khoo CM. Ethnic differences in the role of adipocytokines linking abdominal adiposity and insulin sensitivity among Asians. J Clin Endocrinol Metab 2015 Aug 26:jc20152639. [Epub ahead of print]
3. Than A, He HL, Chua SH, Xu D, Sun L, Leow MK, Chen P. Apelin enhances brown adipogenesis and browning of white adipocytes. J Biol Chem 2015; 290(23): 14679-91. “pii: jbc.M115.643817”
4. Leow MK, Goede S.The Homeostatic Set Point of the Hypothalamus-Pituitary-Thyroid Axis: Maximum Curvature Theory for Personalized Euthyroid Targets. Theor Biol Med Model 2014; 11(1):35
5. Goede S, Leow MK, Smit JW, Dietrich JW. Clinical applications of a thyrotropin-free thyroxine relationship model. Math Biosci 2014; 249:1-7. doi:10.1016/j.mbs.2014.01.001.
6. Khoo CM, Leow MK, Sadananthan SA, et al. Body fat partitioning does not explain the inter-ethnic variation in insulin sensitivity among Asian ethnicity: the Singapore Adults Metabolism Study (SAMS). Diabetes 2013; 63:1093-102.
7. Than A, Cheng YQ, Foh LC, Leow MK, Lim SC, Chuah YJ, Kang Y, Chen P. Apelin inhibits Adipogenesis and Lipolysis. Mol Cellular Endocrinol 2012; 362:227-41.
8. Leow MK, Loh KC, Zhu M, Chan SP, Sundram FX. Iodine-131 Therapy for Hyperthyroidism Prescribed by Endocrinologist – Our Preliminary Experience. Exp Clin Endocrinol Diabetes 2009; 117: 616-21.
9. Leow MK, Chew DE, Zhu M, Soon PC. Thyrotoxicosis and Acute Abdomen – Still As Defying and Misunderstood Today? Brief Observations Over the Recent Decade. QJM 2008; 101:943-7.
10. Leow MK. A Mathematical Model of Pituitary-Thyroid Interaction to Provide an Insight into the Nature of the Thyrotropin-Thyroid Hormone Relationship. J Theor Biol 2007; 248: 275-87.
Please click here for list of publications on PubMed.