Assistant Professor Enci Mary Kan


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Assistant Professor Enci Mary Kan
Adjunct Assistant Professor (Honorary) Medical Technology






Asst Prof Enci Mary Kan is an Assistant Professor of Medical Technology in Lee Kong Chian School of Medicine, Nanyang Technological University. Asst Prof Kan obtained her BSc Biochemistry and MSc Pharmacology from Imperial College London and King’s College London in 2006 and 2007 respectively. She then returned to Singapore and spent >8 years at the Combat Care Laboratory at DSO National Laboratories, carrying out preclinical and clinical research focused on battlefield injuries. Asst Prof Kan completed her PhD in Neuroscience with the National University of Singapore in 2014, where she studied the pathophysiology of mild traumatic brain injury induced cognitive dysfunction in a preclinical model. Asst Prof Kan also worked as a postdoctoral fellow with Stanford Biodesign in 2015, under the umbrella of the Singapore-Stanford Biodesign programme.

Research Focus
Asst Prof Kan seeks to utilize the tenets of biodesign to apply a systematic approach to assess unmet clinical needs in developed and developing countries. Armed with these insights, the goal is to invent meaningful, affordable medical technology solutions that deliver impact to the patient and physician. Through this work, Asst Prof Kan will assist in the planning and development of a new medical technology initiative at NTU and LKC Medicine; facilitating cross-institutional partnerships with other agencies, health services and industry; with emphasis in the fields of surgery and trauma care. Asst Prof Kan’s current work includes developing a medical device for endoscopic biopsy and a wearable device for chronic venous insufficiency.

Key Publications
1. SV Kumar, Kan EM, Lu J, Ng KC, Ling EA, Seramani S, KN BP, Wong YC, Tan MH, Velan SS. Multi-echo Susceptibility Weighted Imaging of Blast-Induced Traumatic Brain Injury in a Rodent Model. NMR Biomed. 2015 Sep;28(9):1069-77. doi: 10.1002/nbm.3351

2. Zou YY, Yuan Y, Kan EM, Lu J, Ling EA. Combustion smoke-induced inflammation in the olfactory bulb of adult rats. J Neuroinflammation. 2014 Oct 10;11:176. doi: 10.1186/s12974-014-0176-

3. Chong SJ, Kan EM, Song C, Soh CR, Lu J: Characterization of early thermal burns and the effects of hyperbaric oxygen treatment: a pilot study. Diving Hyperb Med. 2013 Sep;43(3):157-61.

4. Zou YY, Kan EM, Lu J, Ng KC, Tan MH, Ling EA: Primary Blast Injury-Induced Lesions in the Retina of Adult Rats. J Neuroinflammation 2013. 10:79. doi: 10.1186/1742-2094-10-79.

5. Yao L, Kan EM, Lu J, Hao A, Dheen ST, Kaur C, Ling EA: Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia. J Neuroinflammation 2013, 10:23.

6. Li X, Kan EM, Lu J, Cao Y, Wong RK, Keshavarzian A, Wilder-Smith CH. Combat-training increases intestinal permeability, immune activation and gastrointestinal symptoms in soldiers. Aliment Pharmacol Ther. 2013 Apr;37(8):799-809. doi: 10.1111/apt.12269.

7. Pun PB, Lu J, Kan EM, Moochhala S: Gases in the mitochondria. Mitochondrion 2010, 10:83-93.

8. Lu J, Ng KC, Ling G, Wu J, Poon DJ, Kan EM, Tan MH, Wu YJ, Li P, Moochhala S, et al: Effect of blast exposure on the brain structure and cognition in Macaca fascicularis. J Neurotrauma 2012, 29:1434-1454.

9. Kan EM, Ling EA, Lu J: Microenvironment changes in mild traumatic brain injury. Brain Res Bull 2012, 87:359-372.

10. Kan EM, Ling EA, Lu J: Stem cell therapy for spinal cord injury. Curr Med Chem 2010, 17:4492-4510.
Patents and Disclosures
1. PCT/US16/21880 Devices and methods for analysis of tissue. Filed March 10 2016.