Dr Jayantha Gunaratne obtained his PhD (2003) from the Tokyo Institute of Technology, Japan under a Japanese Government Scholarship program (Monbu-kagaku-sho), where he worked on the biochemical characterisation of bioactive glycoproteins using chromatography, mass spectrometry and NMR-based approaches. He served as a Lecturer and Senior Lecturer in Clinical Biochemistry at the Faculty of Medicine, University of Ruhuna Sri Lanka for about 4 years. In 2004, he joined Scripps Institution, University of California San Diego, USA as a research scholar to pursue his postdoctoral work during which he published several peer-reviewed papers.
In 2007, he moved to Singapore as a founder member of the Mass Spectrometry and Systems Biology Laboratory at the Institute of Molecular and Cellular Biology IMCB, Agency for Science, Technology and Research (A*STAR) Singapore. He was actively involved in establishing advanced Mass Spectrometry-based stable -isotope labeling by amino acids in cell culture (SILAC) technology in Singapore, a powerful approach for quantitative biology. Based on this technology he initiated several discovery biomedical research projects and established over 20 collaborations with world-class scientists, with much of the work leading to publications in high impact journals. Since 2011 he has been heading the Quantitative Proteomics Group of IMCB Translational Research Division as a Group Leader. He leads high quality clinical translational research projects mainly in the area of cancer diagnostic/therapeutic marker discovery and small molecule drug target identification using clinical and chemical proteomics approaches in collaborations with clinicians at the National University Hospital and Duke-NUS. He has been a lecturer in Advanced Proteomics module in IMCB postgraduate course. He also now joins LKCMedicine as Adjunct Senior Lecturer, adding to his adjunct position at Cancer Science Institute, Yong Loo Lin School of Medicine, NUS.